Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2009-1-28
pubmed:abstractText
Mechanical failure of soft tissues is characteristic of life-threatening diseases, including capillary stress failure, pulmonary emphysema, and vessel wall aneurysms. Failure occurs when mechanical forces are sufficiently high to rupture the enzymatically weakened extracellular matrix (ECM). Elastin, an important structural ECM protein, is known to stretch beyond 200% strain before failing. However, ECM constructs and native vessel walls composed primarily of elastin and proteoglycans (PGs) have been found to fail at much lower strains. In this study, we hypothesized that PGs significantly contribute to tissue failure. To test this, we developed a zipper network model (ZNM), in which springs representing elastin are organized into long wavy fibers in a zipper-like formation and placed within a network of springs mimicking PGs. Elastin and PG springs possessed distinct mechanical and failure properties. Simulations using the ZNM showed that the failure of PGs alone reduces the global failure strain of the ECM well below that of elastin, and hence, digestion of elastin does not influence the failure strain. Network analysis suggested that whereas PGs drive the failure process and define the failure strain, elastin determines the peak and failure stresses. Predictions of the ZNM were experimentally confirmed by measuring the failure properties of engineered elastin-rich ECM constructs before and after digestion with trypsin, which cleaves the core protein of PGs without affecting elastin. This study reveals a role for PGs in the failure properties of engineered and native ECM with implications for the design of engineered tissues.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/19144920-10455199, http://linkedlifedata.com/resource/pubmed/commentcorrection/19144920-11165284, http://linkedlifedata.com/resource/pubmed/commentcorrection/19144920-11451749, http://linkedlifedata.com/resource/pubmed/commentcorrection/19144920-11641376, http://linkedlifedata.com/resource/pubmed/commentcorrection/19144920-12021710, http://linkedlifedata.com/resource/pubmed/commentcorrection/19144920-12082143, http://linkedlifedata.com/resource/pubmed/commentcorrection/19144920-12683565, http://linkedlifedata.com/resource/pubmed/commentcorrection/19144920-12941655, http://linkedlifedata.com/resource/pubmed/commentcorrection/19144920-14499302, http://linkedlifedata.com/resource/pubmed/commentcorrection/19144920-14499303, http://linkedlifedata.com/resource/pubmed/commentcorrection/19144920-14602268, http://linkedlifedata.com/resource/pubmed/commentcorrection/19144920-15034119, http://linkedlifedata.com/resource/pubmed/commentcorrection/19144920-15448123, http://linkedlifedata.com/resource/pubmed/commentcorrection/19144920-15465889, http://linkedlifedata.com/resource/pubmed/commentcorrection/19144920-15640390, http://linkedlifedata.com/resource/pubmed/commentcorrection/19144920-15761827, http://linkedlifedata.com/resource/pubmed/commentcorrection/19144920-15829722, http://linkedlifedata.com/resource/pubmed/commentcorrection/19144920-15929966, http://linkedlifedata.com/resource/pubmed/commentcorrection/19144920-15971713, http://linkedlifedata.com/resource/pubmed/commentcorrection/19144920-16316659, http://linkedlifedata.com/resource/pubmed/commentcorrection/19144920-16524339, http://linkedlifedata.com/resource/pubmed/commentcorrection/19144920-17123548, http://linkedlifedata.com/resource/pubmed/commentcorrection/19144920-17254589, http://linkedlifedata.com/resource/pubmed/commentcorrection/19144920-17540839, http://linkedlifedata.com/resource/pubmed/commentcorrection/19144920-17655483, http://linkedlifedata.com/resource/pubmed/commentcorrection/19144920-17813860, http://linkedlifedata.com/resource/pubmed/commentcorrection/19144920-1894644, http://linkedlifedata.com/resource/pubmed/commentcorrection/19144920-1922002, http://linkedlifedata.com/resource/pubmed/commentcorrection/19144920-2055852, http://linkedlifedata.com/resource/pubmed/commentcorrection/19144920-2231964, http://linkedlifedata.com/resource/pubmed/commentcorrection/19144920-2505639, http://linkedlifedata.com/resource/pubmed/commentcorrection/19144920-3091074, http://linkedlifedata.com/resource/pubmed/commentcorrection/19144920-3141480, http://linkedlifedata.com/resource/pubmed/commentcorrection/19144920-3156852, http://linkedlifedata.com/resource/pubmed/commentcorrection/19144920-7666655, http://linkedlifedata.com/resource/pubmed/commentcorrection/19144920-9029195, http://linkedlifedata.com/resource/pubmed/commentcorrection/19144920-9308916, http://linkedlifedata.com/resource/pubmed/commentcorrection/19144920-9659880, http://linkedlifedata.com/resource/pubmed/commentcorrection/19144920-9882642
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1091-6490
pubmed:author
pubmed:issnType
Electronic
pubmed:day
27
pubmed:volume
106
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1081-6
pubmed:dateRevised
2010-9-23
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
A zipper network model of the failure mechanics of extracellular matrices.
pubmed:affiliation
Department of Biomedical Engineering, Boston University, 44 Cummington Street, Boston, MA 02215, USA.
pubmed:publicationType
Journal Article, Research Support, N.I.H., Extramural