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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2010-2-9
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pubmed:abstractText |
Myocarditis is an inflammatory disorder of the heart in which T lymphocytes have a central role. No effective treatment is currently at hand for management of the myocarditis. Lymphocyte function requires the active signal transducer Ras. We thus hypothesized that S-farnesylthiosalicylic acid (FTS), a synthetic small molecule that detaches Ras from the inner cell membrane and induces its rapid degradation, will attenuate experimental autoimmune myocarditis (EAM).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1879-1336
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
94-101
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pubmed:meshHeading |
pubmed-meshheading:19144546-Animals,
pubmed-meshheading:19144546-Autoimmune Diseases,
pubmed-meshheading:19144546-Cell Proliferation,
pubmed-meshheading:19144546-Disease Models, Animal,
pubmed-meshheading:19144546-Enzyme Inhibitors,
pubmed-meshheading:19144546-Farnesol,
pubmed-meshheading:19144546-Heart,
pubmed-meshheading:19144546-Lymph Nodes,
pubmed-meshheading:19144546-Lymphocyte Activation,
pubmed-meshheading:19144546-Myocarditis,
pubmed-meshheading:19144546-Myocardium,
pubmed-meshheading:19144546-Myosins,
pubmed-meshheading:19144546-Rats,
pubmed-meshheading:19144546-Rats, Inbred Lew,
pubmed-meshheading:19144546-Salicylic Acids,
pubmed-meshheading:19144546-Signal Transduction,
pubmed-meshheading:19144546-Swine,
pubmed-meshheading:19144546-T-Lymphocytes,
pubmed-meshheading:19144546-ras Proteins
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pubmed:articleTitle |
The Ras antagonist farnesylthiosalicylic acid ameliorates experimental myocarditis in the rat.
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pubmed:affiliation |
Department of Cardiology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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