Source:http://linkedlifedata.com/resource/pubmed/id/19142572
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
2009-2-9
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pubmed:abstractText |
Cerebrospinal fluid (CSF) concentrations of amyloid-beta (Abeta) 1-38, 1-40, 1-42, total-tau and phospho-tau in samples from 156 patients with Alzheimer's disease (AD) (n = 44), depressive cognitive complainers (DCC, n = 25) and various other forms of non-Alzheimer dementias (NAD, n = 87) were analyzed by electrochemiluminescence and enzyme linked immunosorbent assay, respectively. A significant decrease of CSF Abeta1-42 was the most powerful single marker for differentiation of AD from DCC, yielding accuracies of beyond 85%. Increased p-tau and the ratio Abeta1-42/Abeta1-38 yielded accuracies of beyond 80 and 85%, respectively, to discriminate AD versus NAD. Combining p-tau with Abeta1-42/Abeta1-38 resulted in a sensitivity of 94% for detection of AD and 85% specificity for excluding NAD. Decreased CSF Abeta1-42 represents a core biomarker for AD. The lack of specificity for exclusion of NAD can be most effectively compensated by the ratio Abeta1-42/Abeta1-38. The ratio Abeta1-42/Abeta1-38/p-tau powerfully discriminates AD versus NAD and fulfils the accuracy requirements for an applicable screening and differential diagnostic AD biomarker.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0300-9564
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pubmed:author |
pubmed-author:BiblMirkoM,
pubmed-author:EsselmannHermannH,
pubmed-author:FiegeOliverO,
pubmed-author:KlafkiHans-WolfgangHW,
pubmed-author:KornhuberJohannesJ,
pubmed-author:LewczukPiotrP,
pubmed-author:MollenhauerBritB,
pubmed-author:OttoMarkusM,
pubmed-author:TrenkwalderClaudiaC,
pubmed-author:WelgeVolkerV,
pubmed-author:WiltfangJensJ,
pubmed-author:WolfStefanieS
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pubmed:issnType |
Print
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pubmed:volume |
116
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
203-12
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:19142572-Aged,
pubmed-meshheading:19142572-Alzheimer Disease,
pubmed-meshheading:19142572-Amyloid beta-Peptides,
pubmed-meshheading:19142572-Biological Markers,
pubmed-meshheading:19142572-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:19142572-Female,
pubmed-meshheading:19142572-Humans,
pubmed-meshheading:19142572-Luminescent Measurements,
pubmed-meshheading:19142572-Male,
pubmed-meshheading:19142572-Middle Aged,
pubmed-meshheading:19142572-Phosphorylation,
pubmed-meshheading:19142572-ROC Curve,
pubmed-meshheading:19142572-tau Proteins
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pubmed:year |
2009
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pubmed:articleTitle |
Combined CSF tau, p-tau181 and amyloid-beta 38/40/42 for diagnosing Alzheimer's disease.
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pubmed:affiliation |
Klinik für Psychiatrie und Psychotherapie, Universität Duisburg-Essen, Rheinische Kliniken Essen, Essen, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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