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pubmed-article:19141058pubmed:abstractTextIn this study, we analyzed the gene expression profile of fibroblast-like synoviocyte (FLS) cultures from the temporomandibular joint (TMJ) to identify candidate genes associated with intracapsular pathologic conditions of TMJ. Cyclooxygenase (COX)-2 was one of the genes in FLS upregulated following stimulation by interleukin (IL)-1beta, a cytokine thought to play a key role in several pathological conditions. This study investigated the expression of COX-1 and COX-2 in cultured human FLS and rat TMJ synovium following stimulation with IL-1beta.lld:pubmed
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pubmed-article:19141058pubmed:articleTitleExpression of cyclooxygenase-1 and -2 in IL-1beta-induced synovitis of the temporomandibular joint.lld:pubmed
pubmed-article:19141058pubmed:affiliationDepartment of Maxillofacial Surgery, Nihon University School of Dentistry, Matsudo, Chiba 271-8587, Japan.lld:pubmed
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