Linked Life Data

19139388

Source:http://linkedlifedata.com/resource/pubmed/id/19139388

Statements in which the resource exists.
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pubmed-article:19139388pubmed:abstractTextLow activity of the sarco(endo)plasmic reticulum Ca(2+)-ATPase (SERCA2a) resulting from strong inhibition by phospholamban (PLN) can depress cardiac contractility and lead to dilated cardiomyopathy and heart failure. Here, we investigated whether PLN exhibits cardiotoxic effects via mechanisms other than chronic inhibition of SERCA2a by studying a PLN mutant, PLN(R9C), that triggers cardiac failure in humans and mice.lld:pubmed
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pubmed-article:19139388pubmed:articleTitleAlterations of phospholamban function can exhibit cardiotoxic effects independent of excessive sarcoplasmic reticulum Ca2+-ATPase inhibition.lld:pubmed
pubmed-article:19139388pubmed:affiliationInstitute of Pharmacology and Toxicology, University of Würzburg, Würzburg, Germany. schmitt@toxi.uni-wuerzburg.delld:pubmed
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