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rdf:type |
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lifeskim:mentions |
umls-concept:C0001473,
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0036226,
umls-concept:C0070876,
umls-concept:C0332291,
umls-concept:C0442802,
umls-concept:C0542341,
umls-concept:C0596235,
umls-concept:C1280500,
umls-concept:C1515926
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|
pubmed:issue |
3
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|
pubmed:dateCreated |
2009-1-27
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pubmed:abstractText |
Low activity of the sarco(endo)plasmic reticulum Ca(2+)-ATPase (SERCA2a) resulting from strong inhibition by phospholamban (PLN) can depress cardiac contractility and lead to dilated cardiomyopathy and heart failure. Here, we investigated whether PLN exhibits cardiotoxic effects via mechanisms other than chronic inhibition of SERCA2a by studying a PLN mutant, PLN(R9C), that triggers cardiac failure in humans and mice.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jan
|
|
pubmed:issn |
1524-4539
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|
pubmed:author |
|
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pubmed:issnType |
Electronic
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pubmed:day |
27
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pubmed:volume |
119
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
436-44
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pubmed:meshHeading |
pubmed-meshheading:19139388-Amino Acid Substitution,
pubmed-meshheading:19139388-Animals,
pubmed-meshheading:19139388-Calcium-Binding Proteins,
pubmed-meshheading:19139388-Cell Line,
pubmed-meshheading:19139388-Heart Failure,
pubmed-meshheading:19139388-Humans,
pubmed-meshheading:19139388-Mice,
pubmed-meshheading:19139388-Mice, Transgenic,
pubmed-meshheading:19139388-Phosphorylation,
pubmed-meshheading:19139388-Sarcoplasmic Reticulum Calcium-Transporting ATPases
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|
pubmed:year |
2009
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|
pubmed:articleTitle |
Alterations of phospholamban function can exhibit cardiotoxic effects independent of excessive sarcoplasmic reticulum Ca2+-ATPase inhibition.
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pubmed:affiliation |
Institute of Pharmacology and Toxicology, University of Würzburg, Würzburg, Germany. schmitt@toxi.uni-wuerzburg.de
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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