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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2009-1-16
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pubmed:abstractText |
The combination of artesunate and mefloquine was introduced as the national first-line treatment for Plasmodium falciparum malaria in Cambodia in 2000. However, recent clinical trials performed at the Thai-Cambodian border have pointed to the declining efficacy of both artesunate-mefloquine and artemether-lumefantrine. Since pfmdr1 modulates susceptibility to mefloquine and artemisinin derivatives, the aim of this study was to assess the link between pfmdr1 copy number, in vitro susceptibility to individual drugs and treatment failure to combination therapy.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19138391-10582887,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19138391-10674079,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19138391-11207114,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19138391-12878499,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19138391-14072437,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19138391-15288742,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19138391-15478806,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19138391-15589795,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19138391-15891133,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19138391-16048916,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19138391-16420686,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19138391-16652314,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19138391-16930257,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19138391-17152017,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19138391-17176344,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19138391-17426163,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19138391-1970614,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19138391-394674
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antimalarials,
http://linkedlifedata.com/resource/pubmed/chemical/Artemisinins,
http://linkedlifedata.com/resource/pubmed/chemical/Drug Combinations,
http://linkedlifedata.com/resource/pubmed/chemical/Ethanolamines,
http://linkedlifedata.com/resource/pubmed/chemical/Fluorenes,
http://linkedlifedata.com/resource/pubmed/chemical/Mdr1 protein, Plasmodium falciparum,
http://linkedlifedata.com/resource/pubmed/chemical/Mefloquine,
http://linkedlifedata.com/resource/pubmed/chemical/Multidrug Resistance-Associated...,
http://linkedlifedata.com/resource/pubmed/chemical/artemether-lumefantrine combination,
http://linkedlifedata.com/resource/pubmed/chemical/artesunate
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pubmed:status |
MEDLINE
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pubmed:issn |
1475-2875
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pubmed:author |
pubmed-author:AlkerAlisa PAP,
pubmed-author:ArieyFrédéricF,
pubmed-author:BouchierChristianeC,
pubmed-author:BouthDenis MeyDM,
pubmed-author:FandeurThierryT,
pubmed-author:IncardonaSandraS,
pubmed-author:Le BrasJacquesJ,
pubmed-author:LimPharathP,
pubmed-author:MeshnickSteven RSR,
pubmed-author:NimolKhimK,
pubmed-author:PoravuthYiY,
pubmed-author:PuijalonOdile MercereauOM,
pubmed-author:RingwaldPascalP,
pubmed-author:ShahNaman KNK,
pubmed-author:SocheatDoungD,
pubmed-author:WongsrichanalaiChansudaC
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pubmed:issnType |
Electronic
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
11
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:19138391-Adult,
pubmed-meshheading:19138391-Animals,
pubmed-meshheading:19138391-Antimalarials,
pubmed-meshheading:19138391-Artemisinins,
pubmed-meshheading:19138391-Cambodia,
pubmed-meshheading:19138391-Child,
pubmed-meshheading:19138391-Clinical Trials as Topic,
pubmed-meshheading:19138391-Drug Combinations,
pubmed-meshheading:19138391-Drug Resistance,
pubmed-meshheading:19138391-Ethanolamines,
pubmed-meshheading:19138391-Fluorenes,
pubmed-meshheading:19138391-Gene Dosage,
pubmed-meshheading:19138391-Genetic Variation,
pubmed-meshheading:19138391-Humans,
pubmed-meshheading:19138391-Inhibitory Concentration 50,
pubmed-meshheading:19138391-Malaria, Falciparum,
pubmed-meshheading:19138391-Mefloquine,
pubmed-meshheading:19138391-Multidrug Resistance-Associated Proteins,
pubmed-meshheading:19138391-Plasmodium falciparum,
pubmed-meshheading:19138391-Polymorphism, Genetic,
pubmed-meshheading:19138391-Survival Analysis,
pubmed-meshheading:19138391-Thailand,
pubmed-meshheading:19138391-Treatment Failure
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pubmed:year |
2009
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pubmed:articleTitle |
Pfmdr1 copy number and arteminisin derivatives combination therapy failure in falciparum malaria in Cambodia.
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pubmed:affiliation |
Institut Pasteur in Cambodia, Phnom Penh, Cambodia. pharath@pasteur-kh.org
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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