| pubmed-article:1913836 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1913836 | lifeskim:mentions | umls-concept:C0007452 | lld:lifeskim |
| pubmed-article:1913836 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:1913836 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:1913836 | lifeskim:mentions | umls-concept:C0035499 | lld:lifeskim |
| pubmed-article:1913836 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:1913836 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:1913836 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:1913836 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:1913836 | lifeskim:mentions | umls-concept:C0037791 | lld:lifeskim |
| pubmed-article:1913836 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:1913836 | pubmed:dateCreated | 1991-11-15 | lld:pubmed |
| pubmed-article:1913836 | pubmed:abstractText | Rhodopsin, an integral membrane protein of rod photoreceptor cells, induces an experimental autoimmune uveitis (EAU) when injected into Lewis rats. This disease is characterized by a mononuclear and polymorphonuclear cellular infiltrate of the retina resulting in destruction of the photoreceptor cells. In this study the B and T cell specificities of the response to bovine rhodopsin by Lewis rats were determined. Antibodies induced by injection of rhodopsin were directed almost exclusively to the IV-V loop (residues 174-202). Later in the response, antibody to the N-terminus was also detected. At the T cell level, most activity was directed to the C-terminus as measured by in vitro lymphocyte proliferation. Other minor T cell epitopes were found in the II-III (96-114) and IV-V (174-202) loops. Further dissection of the amino acid sequence responsible for the activity isolated to the C-terminus indicated that a 12-amino acid-long sequence (331-342) elicited the strongest proliferative response. | lld:pubmed |
| pubmed-article:1913836 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1913836 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1913836 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1913836 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1913836 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1913836 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1913836 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1913836 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1913836 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:1913836 | pubmed:issn | 0008-8749 | lld:pubmed |
| pubmed-article:1913836 | pubmed:author | pubmed-author:MotickaE JEJ | lld:pubmed |
| pubmed-article:1913836 | pubmed:author | pubmed-author:AdamusGG | lld:pubmed |
| pubmed-article:1913836 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1913836 | pubmed:volume | 138 | lld:pubmed |
| pubmed-article:1913836 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1913836 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1913836 | pubmed:pagination | 175-84 | lld:pubmed |
| pubmed-article:1913836 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:1913836 | pubmed:meshHeading | pubmed-meshheading:1913836-... | lld:pubmed |
| pubmed-article:1913836 | pubmed:meshHeading | pubmed-meshheading:1913836-... | lld:pubmed |
| pubmed-article:1913836 | pubmed:meshHeading | pubmed-meshheading:1913836-... | lld:pubmed |
| pubmed-article:1913836 | pubmed:meshHeading | pubmed-meshheading:1913836-... | lld:pubmed |
| pubmed-article:1913836 | pubmed:meshHeading | pubmed-meshheading:1913836-... | lld:pubmed |
| pubmed-article:1913836 | pubmed:meshHeading | pubmed-meshheading:1913836-... | lld:pubmed |
| pubmed-article:1913836 | pubmed:meshHeading | pubmed-meshheading:1913836-... | lld:pubmed |
| pubmed-article:1913836 | pubmed:meshHeading | pubmed-meshheading:1913836-... | lld:pubmed |
| pubmed-article:1913836 | pubmed:meshHeading | pubmed-meshheading:1913836-... | lld:pubmed |
| pubmed-article:1913836 | pubmed:meshHeading | pubmed-meshheading:1913836-... | lld:pubmed |
| pubmed-article:1913836 | pubmed:meshHeading | pubmed-meshheading:1913836-... | lld:pubmed |
| pubmed-article:1913836 | pubmed:meshHeading | pubmed-meshheading:1913836-... | lld:pubmed |
| pubmed-article:1913836 | pubmed:meshHeading | pubmed-meshheading:1913836-... | lld:pubmed |
| pubmed-article:1913836 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1913836 | pubmed:articleTitle | Specificity of T and B cell responses to bovine rhodopsin in Lewis rats. | lld:pubmed |
| pubmed-article:1913836 | pubmed:affiliation | Department of Medical Microbiology and Immunology, Southern Illinois University School of Medicine, Springfield 62794-9230. | lld:pubmed |
| pubmed-article:1913836 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1913836 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1913836 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
