Linked Life Data

19136393

Source:http://linkedlifedata.com/resource/pubmed/id/19136393

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2009-5-27
pubmed:abstractText
Our objective was to investigate the impact of methotrexate, paclitaxel, ifosfamide, and cisplatin (M-TIP) on long-term fertility in poor-risk nonseminomatous germ cell tumors (NSGCT). Thirty patients with poor-risk NSGCT (median age, 29 years; range, 17-62 years) were treated with methotrexate 250 mg/m(2) with folinic acid rescue (day 1) and paclitaxel 175 mg/m(2) (day 1), followed by ifosfamide 1.2 g/m(2) and cisplatin 20 mg/m(2) (days 2-6). Treatment consisted of 4 cycles of M-TIP administered every 3 weeks. Twenty-one patients were continuously disease-free at a median follow-up of 5.3 years (range, 0.9-8.4 years). Sperm count and hormonal analyses were examined prechemotherapy (30 patients) and postchemotherapy (21 patients). Counts were classified as follows: lower than 1 x 10(6)/mL, azoospermia; 1-20 x 10(6)/mL, oligospermia (OS); higher than 20 x 10(6)/mL, normospermia (NS). Patients were followed for a median of 2.3 years (range, 0.9-3.8 years) postchemotherapy. The prechemotherapy median luteinizing hormone (LH) serum levels were slightly above the upper normal limit, whereas the serum levels of follicle-stimulating hormone (FSH) and testosterone (T) were within the reference interval. Eleven (52.3%) patients had NS prechemotherapy. Among the patients with NS, 72.7% still had NS following chemotherapy. Overall, 17 of 21 (80.9%; 33.3% OS and 47.6% NS) patients had recovery of spermatogenesis after treatment. The median FSH serum levels were significantly elevated at least 1 year postchemotherapy when compared with the pretreatment levels. Eighteen months after the completion of chemotherapy the median FSH levels had returned to the reference limits. Serum LH and T levels were unaffected by chemotherapy. Prior to chemotherapy 4 of 30 patients had fathered 5 children. Since completion of chemotherapy, 5 patients have fathered 5 children. The majority of men with poor-risk germ cell tumors who were treated with the M-TIP regimen demonstrated recovery spermatogenesis after treatment, and Leydig cell function was unaffected.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1939-4640
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
280-6
pubmed:meshHeading
pubmed-meshheading:19136393-Adolescent, pubmed-meshheading:19136393-Adult, pubmed-meshheading:19136393-Antineoplastic Combined Chemotherapy Protocols, pubmed-meshheading:19136393-Cisplatin, pubmed-meshheading:19136393-Fertility, pubmed-meshheading:19136393-Follicle Stimulating Hormone, pubmed-meshheading:19136393-Humans, pubmed-meshheading:19136393-Ifosfamide, pubmed-meshheading:19136393-Luteinizing Hormone, pubmed-meshheading:19136393-Male, pubmed-meshheading:19136393-Mediastinal Neoplasms, pubmed-meshheading:19136393-Methotrexate, pubmed-meshheading:19136393-Middle Aged, pubmed-meshheading:19136393-Neoplasms, Germ Cell and Embryonal, pubmed-meshheading:19136393-Paclitaxel, pubmed-meshheading:19136393-Risk Factors, pubmed-meshheading:19136393-Spermatogenesis, pubmed-meshheading:19136393-Spermatozoa, pubmed-meshheading:19136393-Testicular Neoplasms, pubmed-meshheading:19136393-Testis, pubmed-meshheading:19136393-Testosterone, pubmed-meshheading:19136393-Young Adult
pubmed:articleTitle
Testicular function in poor-risk nonseminomatous germ cell tumors treated with methotrexate, paclitaxel, ifosfamide, and cisplatin combination chemotherapy.
pubmed:affiliation
Second Department of Internal Medicine, Propaedeutic, Oncology Section, University of Athens, Attikon University Hospital, Rimini 1, Haidari, Athens, Greece. pectasid@otenet.gr
pubmed:publicationType
Journal Article, Clinical Trial