Linked Life Data

19133978

Source:http://linkedlifedata.com/resource/pubmed/id/19133978

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2009-2-3
pubmed:abstractText
Increased levels of naturally occurring regulatory T cells (T(Reg) cells) have been found in a variety of solid tumours and haematological malignancies. In multiple myeloma (MM), evidence suggests that T(Reg) cells are increased though controversy exists with regards to their function and no relationship to disease stage and treatment has been demonstrated. Here, we demonstrate significantly elevated levels of functional CD4(+)CD25(+)FoxP3(+) T(Reg) cells in a large cohort of patients with MM as well as monoclonal gammopathy of uncertain significance (MGUS) in comparison to age-matched, healthy controls. The frequency of Double Negative T(Reg) cells was also evaluated, demonstrating that these cells were reduced in patients with MM. Furthermore, a characteristic profile of immunomodulatory cytokines in the peripheral blood and bone marrow of patients with MM and MGUS was demonstrated, compared with healthy controls. This data adds further evidence to the understanding of the role of T(Reg) cell subsets in tumour immunology and the fundamentals of the host/tumour immune conflict.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1365-2141
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
144
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
686-95
pubmed:meshHeading
pubmed-meshheading:19133978-Aged, pubmed-meshheading:19133978-Aged, 80 and over, pubmed-meshheading:19133978-Antigens, CD3, pubmed-meshheading:19133978-Antigens, CD4, pubmed-meshheading:19133978-Antigens, CD8, pubmed-meshheading:19133978-CD4-Positive T-Lymphocytes, pubmed-meshheading:19133978-Case-Control Studies, pubmed-meshheading:19133978-Cytokines, pubmed-meshheading:19133978-Female, pubmed-meshheading:19133978-Flow Cytometry, pubmed-meshheading:19133978-Forkhead Transcription Factors, pubmed-meshheading:19133978-Humans, pubmed-meshheading:19133978-Immunophenotyping, pubmed-meshheading:19133978-Interleukin-2 Receptor alpha Subunit, pubmed-meshheading:19133978-Lymphocyte Count, pubmed-meshheading:19133978-Male, pubmed-meshheading:19133978-Middle Aged, pubmed-meshheading:19133978-Multiple Myeloma, pubmed-meshheading:19133978-Paraproteinemias, pubmed-meshheading:19133978-Receptors, Antigen, T-Cell, alpha-beta, pubmed-meshheading:19133978-Statistics, Nonparametric, pubmed-meshheading:19133978-T-Lymphocyte Subsets, pubmed-meshheading:19133978-T-Lymphocytes, Regulatory
pubmed:year
2009
pubmed:articleTitle
CD4(+)CD25(+)FoxP3(+) regulatory T cells are increased whilst CD3(+)CD4(-)CD8(-)alphabetaTCR(+) Double Negative T cells are decreased in the peripheral blood of patients with multiple myeloma which correlates with disease burden.
pubmed:affiliation
Transplant Immunology Group, Academic Department of Oncology & Haematology, University of Leeds, Leeds, UK.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't