Linked Life Data

19130495

Source:http://linkedlifedata.com/resource/pubmed/id/19130495

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2009-2-9
pubmed:abstractText
Degeneration of the dopaminergic neurons of the substantia nigra pars compacta in Parkinson's disease induces an abnormal activation of the glutamatergic neurotransmission system within the basal ganglia network and related structures. The aim of this study was to use proton MRS to show metabolic changes in the striatum of 6-hydroxydopamine-lesioned rats, a rodent animal model of Parkinson's disease. Animals were examined before and after extensive lesioning of the nigral dopaminergic neurons and after acute administration of L-3,4-dihydroxyphenylalanine. No significant alterations in glutamate concentrations, assessed by the MR signal dominated by glutamate with minor contributions from glutamine and gamma-aminobutyric acid, could be measured. The total choline/total creatine ratio was found to be reduced in the striatum of the ipsilateral hemisphere.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0952-3480
pubmed:author
pubmed:copyrightInfo
Copyright (c) 2008 John Wiley & Sons, Ltd.
pubmed:issnType
Print
pubmed:volume
22
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
207-12
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Assessment of metabolic changes in the striatum of a rat model of parkinsonism: an in vivo (1)H MRS study.
pubmed:affiliation
INSERM U836, Grenoble Institut des Neurosciences, BP 170, F-38042 Grenoble Cedex 9, France. Nils.Kickler@epfl.ch
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't