Source:http://linkedlifedata.com/resource/pubmed/id/19128592
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
2009-1-8
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pubmed:abstractText |
Chronic rhinosinusitis (CRS) is believed to reflect an inflammatory response of the sinonasal mucosa to bacteria and/or fungi. Staphylococcus aureus, a gram-positive organism, is frequently implicated. Toll-like receptor 2 (TLR2) is involved in innate immunity, recognizing gram-positive organisms via detection of bacterial lipopeptides. As a poor response to sinus surgery has been associated with reduced levels of TLR2 expression, and given the frequent recovery of S. aureus in this condition, we suspected that polymorphisms in TLR2 genes are implicated in this condition.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1916-0216
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
37
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
552-8
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pubmed:meshHeading |
pubmed-meshheading:19128592-Adult,
pubmed-meshheading:19128592-Case-Control Studies,
pubmed-meshheading:19128592-Chi-Square Distribution,
pubmed-meshheading:19128592-Chronic Disease,
pubmed-meshheading:19128592-Female,
pubmed-meshheading:19128592-Genotype,
pubmed-meshheading:19128592-Humans,
pubmed-meshheading:19128592-Male,
pubmed-meshheading:19128592-Polymorphism, Single Nucleotide,
pubmed-meshheading:19128592-Prospective Studies,
pubmed-meshheading:19128592-Rhinitis,
pubmed-meshheading:19128592-Sinusitis,
pubmed-meshheading:19128592-Toll-Like Receptor 2
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pubmed:year |
2008
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pubmed:articleTitle |
Assessment of Toll-like receptor 2 gene polymorphisms in severe chronic rhinosinusitis.
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pubmed:affiliation |
Department of Otolaryngology, Montreal General Hospital, McGill University, Montreal , Quebec. marc.tewfik@mail.mcgill.ca
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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