Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2009-1-14
pubmed:abstractText
Angiogenesis, the synthesis of new blood vessels from preexisting vessels, plays a critical role in normal wound healing and tumor growth. HKa (cleaved high molecular weight kininogen) is an endogenous inhibitor of angiogenesis formed by the cleavage of kininogen on endothelial cells. Ferritin is a protein principally known for its central role in iron storage. Here, we demonstrate that ferritin binds to HKa with high affinity (K(d) 13 nM). Further, ferritin antagonizes the antiangiogenic effects of HKa, enhancing the migration, assembly, and survival of HKa-treated endothelial cells. Effects of ferritin were independent of its iron content. Peptide mapping revealed that ferritin binds to a 22-aa subdomain of HKa that is critical to its antiangiogenic activity. In vivo, ferritin opposed HKa's antiangiogenic effects in a human prostate cancer xenograft, restoring tumor-dependent vessel growth. Ferritin-mediated regulation of angiogenesis represents a new angiogenic regulatory pathway, and identifies a new role for ferritin in cell biology.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/19126685-10627460, http://linkedlifedata.com/resource/pubmed/commentcorrection/19126685-10928277, http://linkedlifedata.com/resource/pubmed/commentcorrection/19126685-11099478, http://linkedlifedata.com/resource/pubmed/commentcorrection/19126685-11258675, http://linkedlifedata.com/resource/pubmed/commentcorrection/19126685-11319821, http://linkedlifedata.com/resource/pubmed/commentcorrection/19126685-11557667, http://linkedlifedata.com/resource/pubmed/commentcorrection/19126685-11986201, http://linkedlifedata.com/resource/pubmed/commentcorrection/19126685-12071855, http://linkedlifedata.com/resource/pubmed/commentcorrection/19126685-12196635, http://linkedlifedata.com/resource/pubmed/commentcorrection/19126685-1370494, http://linkedlifedata.com/resource/pubmed/commentcorrection/19126685-14506238, http://linkedlifedata.com/resource/pubmed/commentcorrection/19126685-14644197, http://linkedlifedata.com/resource/pubmed/commentcorrection/19126685-15733059, http://linkedlifedata.com/resource/pubmed/commentcorrection/19126685-16259723, http://linkedlifedata.com/resource/pubmed/commentcorrection/19126685-16305348, http://linkedlifedata.com/resource/pubmed/commentcorrection/19126685-16507405, http://linkedlifedata.com/resource/pubmed/commentcorrection/19126685-16842160, http://linkedlifedata.com/resource/pubmed/commentcorrection/19126685-1701519, http://linkedlifedata.com/resource/pubmed/commentcorrection/19126685-1764477, http://linkedlifedata.com/resource/pubmed/commentcorrection/19126685-17699375, http://linkedlifedata.com/resource/pubmed/commentcorrection/19126685-18062965, http://linkedlifedata.com/resource/pubmed/commentcorrection/19126685-18083163, http://linkedlifedata.com/resource/pubmed/commentcorrection/19126685-18192590, http://linkedlifedata.com/resource/pubmed/commentcorrection/19126685-19193849, http://linkedlifedata.com/resource/pubmed/commentcorrection/19126685-2076473, http://linkedlifedata.com/resource/pubmed/commentcorrection/19126685-3730610, http://linkedlifedata.com/resource/pubmed/commentcorrection/19126685-3828232, http://linkedlifedata.com/resource/pubmed/commentcorrection/19126685-7642598, http://linkedlifedata.com/resource/pubmed/commentcorrection/19126685-8144509, http://linkedlifedata.com/resource/pubmed/commentcorrection/19126685-8203285, http://linkedlifedata.com/resource/pubmed/commentcorrection/19126685-8664805, http://linkedlifedata.com/resource/pubmed/commentcorrection/19126685-8985824, http://linkedlifedata.com/resource/pubmed/commentcorrection/19126685-9593701
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1091-6490
pubmed:author
pubmed:issnType
Electronic
pubmed:day
13
pubmed:volume
106
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
570-5
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Regulatory effects of ferritin on angiogenesis.
pubmed:affiliation
Program in Molecular Medicine, Wake Forest University School of Medicine, Winston Salem NC 27157, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural