19116766

Source:http://linkedlifedata.com/resource/pubmed/id/19116766

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0037083, umls-concept:C0085536, umls-concept:C0086418, umls-concept:C0225336, umls-concept:C0330390, umls-concept:C0851285, umls-concept:C1710082
pubmed:issue	1
pubmed:dateCreated	2009-2-26
pubmed:abstractText	The endothelial cell (EC)-selective receptor tyrosine kinase, Tie2, and its ligands angiopoietin Ang-1 and Ang-2, are essential for blood vessel maintenance and repair. Ang-1 is an agonist of Tie2 receptor activation, whereas Ang-2 is a context-dependent antagonist/agonist. Therefore, we investigated the role of the EC-selective phosphatase, human protein tyrosine phosphatase beta (HPTPbeta), in regulating Tie2 activity.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9814575
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Angiopoietin-1, http://linkedlifedata.com/resource/pubmed/chemical/Angiopoietin-2, http://linkedlifedata.com/resource/pubmed/chemical/Angiopoietins, http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger, http://linkedlifedata.com/resource/pubmed/chemical/RNA, Small Interfering, http://linkedlifedata.com/resource/pubmed/chemical/Receptor, TIE-2, http://linkedlifedata.com/resource/pubmed/chemical/Receptor-Like Protein Tyrosine..., http://linkedlifedata.com/resource/pubmed/chemical/Vanadates
pubmed:status	MEDLINE
pubmed:issn	1573-7209
pubmed:author	pubmed-author:ForseKellyK, pubmed-author:JuraszPaulP, pubmed-author:LaiPatrick F HPF, pubmed-author:StewartDuncan JDJ, pubmed-author:Teichert-KuliszewskaKrystynaK, pubmed-author:YacyshynOrisha KOK
pubmed:issnType	Electronic
pubmed:volume	12
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	25-33
pubmed:dateRevised	2009-11-19
pubmed:meshHeading	pubmed-meshheading:19116766-Angiopoietin-1, pubmed-meshheading:19116766-Angiopoietin-2, pubmed-meshheading:19116766-Angiopoietins, pubmed-meshheading:19116766-Cell Hypoxia, pubmed-meshheading:19116766-Cell Movement, pubmed-meshheading:19116766-Cell Survival, pubmed-meshheading:19116766-Cells, Cultured, pubmed-meshheading:19116766-Endothelial Cells, pubmed-meshheading:19116766-Gene Expression Regulation, Enzymologic, pubmed-meshheading:19116766-Humans, pubmed-meshheading:19116766-Phosphorylation, pubmed-meshheading:19116766-RNA, Messenger, pubmed-meshheading:19116766-RNA, Small Interfering, pubmed-meshheading:19116766-Receptor, TIE-2, pubmed-meshheading:19116766-Receptor-Like Protein Tyrosine Phosphatases, Class 5, pubmed-meshheading:19116766-Signal Transduction, pubmed-meshheading:19116766-Vanadates
pubmed:year	2009
pubmed:articleTitle	Tyrosine phosphatase beta regulates angiopoietin-Tie2 signaling in human endothelial cells.
pubmed:affiliation	Terrence Donnelly Heart Centre and Division of Cardiology, St Michael's Hospital, 30 Bond Street, Toronto, Ontario, Canada.
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't