Source:http://linkedlifedata.com/resource/pubmed/id/19104080
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
|
| pubmed:dateCreated |
2009-2-20
|
| pubmed:abstractText |
We made a disease-specific comparison of unrelated cord blood (CB) recipients and human leukocyte antigen allele-matched unrelated bone marrow (BM) recipients among 484 patients with acute myeloid leukemia (AML; 173 CB and 311 BM) and 336 patients with acute lymphoblastic leukemia (ALL; 114 CB and 222 BM) who received myeloablative transplantations. In multivariate analyses, among AML cases, lower overall survival (hazard ratio [HR]=1.5; 95% confidence interval [CI], 1.0-2.0, P= .028) and leukemia-free survival (HR=1.5; 95% CI, 1.1-2.0, P= .012) were observed in CB recipients. The relapse rate did not differ between the 2 groups of AML (HR=1.2; 95% CI, 0.8-1.9, P= .38); however, the treatment-related mortality rate showed higher trend in CB recipients (HR=1.5; 95% CI, 1.0-2.3, P= .085). In ALL, there was no significant difference between the groups for relapse (HR=1.4, 95% CI, 0.8-2.4, P= .19) and treatment-related mortality (HR=1.0; 95% CI, 0.6-1.7, P= .98), which contributed to similar overall survival (HR=1.1; 95% CI, 0.7-1.6, P= .78) and leukemia-free survival (HR=1.2; 95% CI, 0.9-1.8, P= .28). Matched or mismatched single-unit CB is a favorable alternative stem cell source for patients without a human leukocyte antigen-matched related or unrelated donor. For patients with AML, decreasing mortality, especially in the early phase of transplantation, is required to improve the outcome for CB recipients.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:status |
MEDLINE
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| pubmed:month |
Feb
|
| pubmed:issn |
1528-0020
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| pubmed:author |
pubmed-author:AtsutaYoshikoY,
pubmed-author:AzumaHiroshiH,
pubmed-author:FukudaTakahiroT,
pubmed-author:Japan Cord Blood Bank Network,
pubmed-author:KaiShunroS,
pubmed-author:KasaiMasaharuM,
pubmed-author:KatoShunichiS,
pubmed-author:KawaKeiseiK,
pubmed-author:KoderaYoshihisaY,
pubmed-author:KouzaiYasushiY,
pubmed-author:MorishimaYasuoY,
pubmed-author:Nagamura-InoueTokikoT,
pubmed-author:OkamotoShinichiroS,
pubmed-author:SakamakiHisashiH,
pubmed-author:SuzukiRitsuroR,
pubmed-author:TakahashiSatoshiS,
pubmed-author:TakanashiMinokoM,
pubmed-author:TaniguchiShuichiS,
pubmed-author:TsuchidaMasahiroM
|
| pubmed:issnType |
Electronic
|
| pubmed:day |
19
|
| pubmed:volume |
113
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1631-8
|
| pubmed:meshHeading |
pubmed-meshheading:19104080-Adolescent,
pubmed-meshheading:19104080-Adult,
pubmed-meshheading:19104080-Aged,
pubmed-meshheading:19104080-Blood Platelets,
pubmed-meshheading:19104080-Bone Marrow Transplantation,
pubmed-meshheading:19104080-Cause of Death,
pubmed-meshheading:19104080-Cord Blood Stem Cell Transplantation,
pubmed-meshheading:19104080-Disease-Free Survival,
pubmed-meshheading:19104080-Female,
pubmed-meshheading:19104080-Follow-Up Studies,
pubmed-meshheading:19104080-Graft vs Host Disease,
pubmed-meshheading:19104080-Histocompatibility Testing,
pubmed-meshheading:19104080-Humans,
pubmed-meshheading:19104080-Incidence,
pubmed-meshheading:19104080-Leukemia, Myeloid, Acute,
pubmed-meshheading:19104080-Male,
pubmed-meshheading:19104080-Middle Aged,
pubmed-meshheading:19104080-Multivariate Analysis,
pubmed-meshheading:19104080-Neutrophils,
pubmed-meshheading:19104080-Precursor Cell Lymphoblastic Leukemia-Lymphoma,
pubmed-meshheading:19104080-Recurrence,
pubmed-meshheading:19104080-Risk Factors,
pubmed-meshheading:19104080-Treatment Outcome,
pubmed-meshheading:19104080-Young Adult
|
| pubmed:year |
2009
|
| pubmed:articleTitle |
Disease-specific analyses of unrelated cord blood transplantation compared with unrelated bone marrow transplantation in adult patients with acute leukemia.
|
| pubmed:affiliation |
Department of Hematopoietic Stem Cell Transplantation Data Management, Nagoya University School of Medicine, Higashi-ku Nagoya, Japan. y-atsuta@med.nagoya-u.ac.jp
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Research Support, Non-U.S. Gov't
|