Linked Life Data

19101152

Source:http://linkedlifedata.com/resource/pubmed/id/19101152

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2009-1-26
pubmed:abstractText
Copper-64 (t(1/2)=12.7h; beta(+): 0.653 MeV, 17.4%; beta(-): 0.578 MeV, 39%) is produced in a biomedical cyclotron and has applications in both imaging and therapy. Macrocyclic chelators are widely used as bifunctional chelators to bind copper radionuclides to antibodies and peptides owing to their relatively high kinetic stability. A novel side-bridged cyclam featuring both pendant acetate and phosphonate groups was synthesized using a Kabachnik-Fields approach followed by hydrobromic acid deprotection. The Cu(II) complex of the novel ligand was synthesized, radiolabeling with (64)Cu was demonstrated, and in vitro (serum) stability was performed. In addition, in vivo distribution and clearance of the (64)Cu-labeled complex was visualized by positron emission tomography (PET) imaging. This novel chelate may be useful in (64)Cu-mediated diagnostic positron emission tomography (PET) imaging as well as targeted radiotherapeutic applications.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/19101152-10100704, http://linkedlifedata.com/resource/pubmed/commentcorrection/19101152-10628566, http://linkedlifedata.com/resource/pubmed/commentcorrection/19101152-11216519, http://linkedlifedata.com/resource/pubmed/commentcorrection/19101152-11735465, http://linkedlifedata.com/resource/pubmed/commentcorrection/19101152-11789022, http://linkedlifedata.com/resource/pubmed/commentcorrection/19101152-11922786, http://linkedlifedata.com/resource/pubmed/commentcorrection/19101152-12459917, http://linkedlifedata.com/resource/pubmed/commentcorrection/19101152-14998334, http://linkedlifedata.com/resource/pubmed/commentcorrection/19101152-15623652, http://linkedlifedata.com/resource/pubmed/commentcorrection/19101152-15691659, http://linkedlifedata.com/resource/pubmed/commentcorrection/19101152-16094480, http://linkedlifedata.com/resource/pubmed/commentcorrection/19101152-17308678, http://linkedlifedata.com/resource/pubmed/commentcorrection/19101152-17458949, http://linkedlifedata.com/resource/pubmed/commentcorrection/19101152-17592589, http://linkedlifedata.com/resource/pubmed/commentcorrection/19101152-3258025, http://linkedlifedata.com/resource/pubmed/commentcorrection/19101152-8523125, http://linkedlifedata.com/resource/pubmed/commentcorrection/19101152-9080473, http://linkedlifedata.com/resource/pubmed/commentcorrection/19101152-9101324, http://linkedlifedata.com/resource/pubmed/commentcorrection/19101152-9829587
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1464-3391
pubmed:author
pubmed:issnType
Electronic
pubmed:day
15
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
548-52
pubmed:dateRevised
2010-9-23
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
A novel side-bridged hybrid phosphonate/acetate pendant cyclam: synthesis, characterization, and 64Cu small animal PET imaging.
pubmed:affiliation
Radioimmune and Inorganic Chemistry Section, Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Building 10 Center Drive, Bethesda, MA 20892-1088, United States.
pubmed:publicationType
Journal Article, Research Support, N.I.H., Intramural