Linked Life Data

19097220

Source:http://linkedlifedata.com/resource/pubmed/id/19097220

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2008-12-24
pubmed:abstractText
There is increasing interest in quantitative T(1) mapping techniques for a variety of applications. Several methods for T(1) quantification have been described. The acquisition of two spoiled gradient-echo data sets with different flip angles allows for the calculation of T(1) maps with a high spatial resolution and a relatively short experimental duration. However, the method requires complete spoiling of transverse magnetization. To achieve this goal, RF spoiling has to be applied. In this work it is investigated whether common RF spoiling techniques are sufficiently effective to allow for accurate T(1) quantification. It is shown that for most phase increments the apparent T(1) can deviate considerably from the true value. Correct results may be achieved with phase increments of 118.2 degrees or 121.8 degrees. However, for these values the method suffers from instabilities. In contrast, stable results are obtained with a phase increment of 50 degrees. An algorithm is presented that allows for the calculation of corrected T(1) maps from the apparent values. The method is tested both in phantom experiments and in vivo by acquiring whole-brain T(1) maps of the human brain.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1522-2594
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
61
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
125-35
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Influence of RF spoiling on the stability and accuracy of T1 mapping based on spoiled FLASH with varying flip angles.
pubmed:affiliation
Brain Imaging Center, University Hospital, Frankfurt, Germany. preibisch@em.uni-frankfurt.de
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't