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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
1991-9-26
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pubmed:abstractText |
Studies on fatty acid oxidation were made in rats fed for 6 months on a liquid diet containing 15% total calories as ethanol. After 6 months, a marked diminution was observed in the in vivo production of 14CO2 from labeled palmitate and octanoate in the ethanol-fed animals compared to their pair-fed isocaloric controls not receiving alcohol. Similar results were obtained in 14CO2 formation from 14C-fatty acids using liver mitochondria from these ethanol-fed rats after 6 months. The effect on octanoate beta-oxidation was larger than that for palmitate. Addition of purified acyl CoA dehydrogenase complexes and additional electron transfer flavoprotein complex to the mitochondria suggested that the ethanol-fed animals could have been deficient in the medium-chain acyl CoA-dehydrogenase complex.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0741-8329
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
241-6
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:1908248-Alcoholism,
pubmed-meshheading:1908248-Animals,
pubmed-meshheading:1908248-Carbon Dioxide,
pubmed-meshheading:1908248-Lipid Metabolism,
pubmed-meshheading:1908248-Male,
pubmed-meshheading:1908248-Mitochondria, Liver,
pubmed-meshheading:1908248-Oxidation-Reduction,
pubmed-meshheading:1908248-Rats,
pubmed-meshheading:1908248-Rats, Inbred Strains
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pubmed:articleTitle |
A probable defect in the beta-oxidation of lipids in rats fed alcohol for 6 months.
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pubmed:affiliation |
Veterans Administration Medical Center, Philadelphia, PA 19104.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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