Linked Life Data

19066749

Source:http://linkedlifedata.com/resource/pubmed/id/19066749

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2008-12-10
pubmed:abstractText
Cardiac troponins play a major role in the diagnostic work-up of acute coronary syndrome/myocardial infarction. Elevations were demonstrated also in other, rather nonischemic diseases like pulmonary embolism or acute heart failure. Stepwise improvement in the accuracy of the commercially available assays allowed detection of low-level concentrations of cardiac troponins, which were previously partially classified to be normal (between the limit of detection and the 99 th percentile by < 10% coefficient of variance). These low concentrations were associated with the detection of chronic cardiovascular pathologies and an increased risk of future cardiovascular events. Recently, ten to 100 times more sensitive assays (so-called high sensitive or ultra sensitive assays) have been developed. The clinical importance of those now measurable troponin values is currently under intensive investigation. The expected additional clinical and prognostic information from such low- and even lowest-level troponin values pose a special challenge. Specifically, the question has been raised, whether the established single cutoff approach for diagnosing myocardial infarction should not be complemented by another, lower cutoff usable for the detection of other (stable) cardiovascular pathologies with lower but still substantial risk.
pubmed:language
ger
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1615-6692
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
33
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
526-31
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
[Recent assay developments for cardiac troponins: are we sensitive enough to recognize the high sensitives?].
pubmed:affiliation
Interventionelle Kardiologie Spandau, Berlin, Germany. oschulz@cath-lab-spandau.de
pubmed:publicationType
Journal Article, English Abstract, Review