|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
2009-2-13
|
|
pubmed:abstractText |
IFN gamma is a pleiotropic cytokine that plays a key role in host resistance, yet when not properly regulated can become detrimental to the host. The interferon-inducible Immunity Related GTPase family M member 1 (Irgm1), previously characterized as an effector molecule required for macrophage microbicidal activity, has been shown recently to control IFN gamma-dependent cell survival and host resistance. Irgm1 regulates the expansion/survival of mature effector CD4(+) T lymphocytes by protecting them from IFN gamma-induced autophagic cell death. Importantly, mice deficient in both IFN gamma and Irgm1 were rescued from the lymphocyte depletion and increased mortality that typically occurs in Irgm1(-/-) animals following pathogen exposure. We propose that Irgm1 plays a major role in maintaining T lymphocyte homeostasis during host IFN gamma responses by protecting these cells from autophagy-dependent cell death.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19066452-14576437,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19066452-14707092,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19066452-15040583,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19066452-15131264,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19066452-15607973,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19066452-16339555,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19066452-16702227,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19066452-16886061,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19066452-16888103,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19066452-17190837,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19066452-17767194,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19066452-18023232,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19066452-18305538,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19066452-18371424,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19066452-18772884,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19066452-18806793,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19066452-7561525,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19066452-9862701
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Feb
|
|
pubmed:issn |
1554-8635
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
5
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
232-4
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:19066452-Animals,
pubmed-meshheading:19066452-Autophagy,
pubmed-meshheading:19066452-CD4-Positive T-Lymphocytes,
pubmed-meshheading:19066452-Cell Survival,
pubmed-meshheading:19066452-GTP-Binding Proteins,
pubmed-meshheading:19066452-Immunity,
pubmed-meshheading:19066452-Interferon-gamma,
pubmed-meshheading:19066452-Lymphocytes,
pubmed-meshheading:19066452-Macrophages,
pubmed-meshheading:19066452-Mice,
pubmed-meshheading:19066452-Models, Biological
|
|
pubmed:year |
2009
|
|
pubmed:articleTitle |
Interferon-inducible immunity-related GTPase Irgm1 regulates IFN gamma-dependent host defense, lymphocyte survival and autophagy.
|
|
pubmed:affiliation |
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892-8003, USA. cfeng@niaid.nih.gov
|
|
pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Intramural
|
