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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
50
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pubmed:dateCreated |
2008-12-17
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pubmed:abstractText |
The contribution of structural remodeling to long-term adult brain plasticity is unclear. Here, we investigate features of GABAergic interneuron dendrite dynamics and extract clues regarding its potential role in cortical function and circuit plasticity. We show that remodeling interneurons are contained within a "dynamic zone" corresponding to a superficial strip of layers 2/3, and remodeling dendrites respect the lower border of this zone. Remodeling occurs primarily at the periphery of dendritic fields with addition and retraction of new branch tips. We further show that dendrite remodeling is not intrinsic to a specific interneuron class. These data suggest that interneuron remodeling is not a feature predetermined by genetic lineage, but rather, it is imposed by cortical laminar circuitry. Our findings are consistent with dynamic GABAergic modulation of feedforward and recurrent connections in response to top-down feedback and suggest a structural component to functional plasticity of supragranular neocortical laminae.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19066223-10195148,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19066223-10341241,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19066223-10777798,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19066223-11086982,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/19066223-14528309,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19066223-15378039,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19066223-1545866,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/19066223-16366735,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/19066223-8395585,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19066223-8421494,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19066223-8713135,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/19066223-9875341
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1091-6490
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
16
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pubmed:volume |
105
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
19968-73
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
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pubmed:year |
2008
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pubmed:articleTitle |
A dynamic zone defines interneuron remodeling in the adult neocortex.
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pubmed:affiliation |
The Picower Institute for Learning and Memory and Departments of Brain and Cognitive Sciences, Biology, and Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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