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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
1991-7-17
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pubmed:abstractText |
The rate of leucine C-2 incorporation into glutamine was compared in control and septic rats. Female Sprague-Dawley rats (n = 46, 210-260 g) were fed parenterally for 3 days and then randomized into two groups (control and septic). Sepsis was induced by the injection of 10(10) live Escherichia coli/kg on day 4 into the septic group. Rats in each group were given a continuous (8 h) infusion of one of three different isotopes. The isotopes were given 24 h after inoculation. Leucine oxidation and incorporation into protein were determined with [1-13C]leucine; glutamine flux and oxidation were determined with [5-13C]glutamine, and the fraction of leucine C-2 incorporated into glutamine was determined by giving [1,2-13C]leucine. Results were as follows: sepsis caused a significant increase in the rate of leucine C-2 incorporation into glutamine (66.0 +/- 3.7 as against 29.6 +/- 3.7 mumol/h per kg, P less than 0.01). This increase was due to both an increase in glutamine production (2331 +/- 76 as against 1959 +/- 94 mumol/h per kg, P less than 0.01) and an increase in the proportion of glutamine derived from leucine (2.83 +/- 0.27% as against 1.51 +/- 0.31%, P less than 0.01). The ratio of leucine C-2 incorporated into glutamine to leucine oxidized increased from 7.16 +/- 0.91% to 11.49 +/- 1.12% with sepsis (P less than 0.05).
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1904718-111363,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1904718-2493105,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1904718-2493121,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1904718-2642438,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1904718-2647433,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1904718-2668703,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1904718-3087215,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1904718-3761022,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1904718-3928024,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1904718-4025827,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1904718-4064562,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1904718-6106558,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1904718-6751244,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1904718-6778978,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1904718-7320199,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1904718-7406567,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1904718-7425121,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1904718-7471641
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0264-6021
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
276 ( Pt 2)
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
405-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:1904718-Animals,
pubmed-meshheading:1904718-Carbon Isotopes,
pubmed-meshheading:1904718-Escherichia coli Infections,
pubmed-meshheading:1904718-Female,
pubmed-meshheading:1904718-Glutamine,
pubmed-meshheading:1904718-Kinetics,
pubmed-meshheading:1904718-Leucine,
pubmed-meshheading:1904718-Mathematics,
pubmed-meshheading:1904718-Models, Biological,
pubmed-meshheading:1904718-Parenteral Nutrition, Total,
pubmed-meshheading:1904718-Rats,
pubmed-meshheading:1904718-Rats, Inbred Strains,
pubmed-meshheading:1904718-Reference Values,
pubmed-meshheading:1904718-Sepsis
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pubmed:year |
1991
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pubmed:articleTitle |
Leucine and glutamine metabolism in septic rats.
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pubmed:affiliation |
Department of Surgery, University of Medicine and Dentistry of New Jersey, School of Osteopathic Medicine, Camden 08103.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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