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Predicate | Object |
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rdf:type | |
lifeskim:mentions |
umls-concept:C0017083,
umls-concept:C0028959,
umls-concept:C0030705,
umls-concept:C0032594,
umls-concept:C0033684,
umls-concept:C0042036,
umls-concept:C0205314,
umls-concept:C0205409,
umls-concept:C0330390,
umls-concept:C0332307,
umls-concept:C0439849,
umls-concept:C0445223,
umls-concept:C0560013,
umls-concept:C0679622,
umls-concept:C1552599,
umls-concept:C1704787,
umls-concept:C1880022
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pubmed:issue |
2
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pubmed:dateCreated |
1991-7-10
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pubmed:abstractText |
Two new oligosaccharides were isolated from the urine of a patient with GM1 gangliosidosis. Final purification of the oligosaccharides was accomplished by capillary supercritical fluid chromatography. Structural analysis was by chemical analysis, chemical-ionization mass spectrometry and 400-MHz 1H-NMR spectroscopy, leading to two primary structures. The first is derived from a classical triantennary N-acetyllactosamine-type glycan: Gal beta 1-4GlcNAc beta 1-4(Gal beta 1-4GlcNAc beta 1-2)Man alpha 1-3Man beta 1-4GlcNAc. The second is unusual with a terminal disaccharide Gal beta 1-6Gal, which had not yet been described for glycans of the N-acetyllactosamine type: Gal beta 1-6Gal beta 1-4GlcNAc beta 1-2Man alpha 1-6Man beta 1-4GlcNAc.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0014-2956
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
198
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
521-6
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pubmed:dateRevised |
2007-7-23
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pubmed:meshHeading |
pubmed-meshheading:1904026-Carbohydrate Conformation,
pubmed-meshheading:1904026-Carbohydrate Sequence,
pubmed-meshheading:1904026-Chromatography, Paper,
pubmed-meshheading:1904026-G(M1) Ganglioside,
pubmed-meshheading:1904026-Gangliosidoses,
pubmed-meshheading:1904026-Glycosylation,
pubmed-meshheading:1904026-Humans,
pubmed-meshheading:1904026-Magnetic Resonance Spectroscopy,
pubmed-meshheading:1904026-Mass Spectrometry,
pubmed-meshheading:1904026-Molecular Sequence Data,
pubmed-meshheading:1904026-Oligosaccharides,
pubmed-meshheading:1904026-Proteoglycans
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pubmed:year |
1991
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pubmed:articleTitle |
Characterization of a novel type of chain-terminator Gal beta 1-6Gal beta 1-4)GlcNAc in an oligosaccharide related to N-glycosylated protein glycans isolated from GM1 the urine of patients with gangliosidosis.
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pubmed:affiliation |
Laboratoire de Chimie Biologique, Unité Mixte de Recherche, Université des Sciences et Techniques de Lille Flandres-Artois, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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