Linked Life Data

19037631

Source:http://linkedlifedata.com/resource/pubmed/id/19037631

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2009-3-20
pubmed:abstractText
The actions of adenosine in the human atrium are of clinical relevance, for instance, to stop supraventricular arrhythmias. The purpose of the present study was to re-evaluate the inotropic effect of adenosine in the human atrium. We studied the effect of adenosine (cumulatively applied) on force of contraction in isolated electrically driven right atrial preparations from patients with coronary heart disease undergoing cardiac surgery. It has been known for some time that adenosine via A(1)-adenosine receptors can elicit a negative inotropic effect in human atrial preparations. We report here that in 25% of the patients studied, a positive inotropic effect to adenosine was detectable. The A(1)-adenosine receptor antagonist 1,3-dipropyl-cyclopentyl-xanthine attenuated this effect. Hence, we conclude that at least in some patients, adenosine can lead to a hitherto overlooked positive inotropic effect.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1432-1912
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
379
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
533-40
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
A positive inotropic effect of adenosine in cardiac preparations of right atria from diseased human hearts.
pubmed:affiliation
Institut für Pharmakologie und Toxikologie, Medizinische Fakultät, Martin-Luther-Universität Halle-Wittenberg, Magdeburger Str. 4, 06112, Halle, Germany.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't