Linked Life Data

19030954

Source:http://linkedlifedata.com/resource/pubmed/id/19030954

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2009-1-6
pubmed:abstractText
Baculovirus-insect cell systems have been widely used over the past decades. However, few studies to date have addressed baculovirus codon usage. In this study, we calculated the effective number of codons (ENC) for all 5,842 ORFs from 42 completely sequenced baculoviruses. The results revealed that most of the baculoviruses lacked strong codon bias (ENC > 35). Exceptions were Lymantria dispar nucleopolyhedrovirus (LdMNPV) and Orgyia pseudotsugata nucleopolyhedrovirus (OpMNPV), which were found to have a strong codon bias (ENC < 35) in 20.9 and 11.8%, respectively, of their total genes. Comparisons of preferred codons based on taxonomic clades showed that the preferred codons were different in different clades, but nine codons (UUU, UAC, UUG, CAC, CAA, AAA, GUG, GAA, and AUU) were preferably adopted by most baculovirus genes. Correspondence analysis showed that the major trend in codon usage variation among all genes significantly correlated with the GC content of sequences. Analyses also suggested that the high condon bias of LdMNPV and OpMNPV were correlated with their high GC%.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1432-8798
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
153
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2273-82
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
An extensive analysis on the global codon usage pattern of baculoviruses.
pubmed:affiliation
State Key Laboratory of Virology, Joint Laboratory of Invertebrate Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, 430071, Wuhan, People's Republic of China.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't