Source:http://linkedlifedata.com/resource/pubmed/id/19021933
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
9
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| pubmed:dateCreated |
2008-11-21
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| pubmed:abstractText |
A 49-year-old man consumed two glasses (approximately 2 x 20 mL) of a beverage containing yellow gentian (Gentiana lutea). Shortly after ingestion, he developed nausea, vomiting, and oral paraesthesia. On admission to the hospital he suffered from severe bradycardia (35 beats/min) and hypotension (50/30 mm Hg), and he was treated with activated charcoal, antiemetics (metoclopramide, ondansetron), atropine, and intravenous electrolytic solution. The initial suspicion of Veratrum poisoning could be confirmed by identifying protoveratrines A (ProA) and protoveratrine B (ProB) in a sample from the beverage as well as in the patients serum by liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS-MS). The yellow-colored beverage contained 25% ethanol (by headspace gas chromatography), 20.4 mg/L ProA, and 13.7 mg/L ProB. The serum concentration of ProA was 1162 ng/L and ProB was 402 ng/L. Veratridine, cevadine, and jervine were not detected, neither in the beverage nor in the serum sample. The lower limits of quantitation for all compounds is 10 microg/L (S/N > 10, beverage) and 100 ng/L (S/N > 10, serum). After treatment, the patient completely recovered from the symptoms within 24 h and was discharged from the hospital. The analytical method described was developed for the simultaneous identification and quantitation of five Veratrum alkaloids. The method is based on a liquid-liquid extraction followed by LC-MS-MS analysis. The time needed for analysis was 6 min.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antidotes,
http://linkedlifedata.com/resource/pubmed/chemical/Antiemetics,
http://linkedlifedata.com/resource/pubmed/chemical/Charcoal,
http://linkedlifedata.com/resource/pubmed/chemical/Indicators and Reagents,
http://linkedlifedata.com/resource/pubmed/chemical/Veratrum Alkaloids
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| pubmed:status |
MEDLINE
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| pubmed:issn |
0146-4760
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
32
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
768-73
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| pubmed:dateRevised |
2009-12-15
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| pubmed:meshHeading |
pubmed-meshheading:19021933-Accidents,
pubmed-meshheading:19021933-Alcoholic Beverages,
pubmed-meshheading:19021933-Antidotes,
pubmed-meshheading:19021933-Antiemetics,
pubmed-meshheading:19021933-Charcoal,
pubmed-meshheading:19021933-Chromatography, High Pressure Liquid,
pubmed-meshheading:19021933-Chromatography, Thin Layer,
pubmed-meshheading:19021933-Gentiana,
pubmed-meshheading:19021933-Hemodynamics,
pubmed-meshheading:19021933-Humans,
pubmed-meshheading:19021933-Indicators and Reagents,
pubmed-meshheading:19021933-Male,
pubmed-meshheading:19021933-Mass Spectrometry,
pubmed-meshheading:19021933-Middle Aged,
pubmed-meshheading:19021933-Spectrometry, Mass, Electrospray Ionization,
pubmed-meshheading:19021933-Spectrophotometry, Ultraviolet,
pubmed-meshheading:19021933-Veratrum,
pubmed-meshheading:19021933-Veratrum Alkaloids
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| pubmed:articleTitle |
Accidental intoxication with Veratrum album.
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| pubmed:affiliation |
Berliner Betrieb für Zentrale Gesundheitliche Aufgaben (BBGes), Institute of Toxicology and Poison Information Centre Berlin, Oranienburger Str. 285, 13437 Berlin, Germany. grobosch.tox@bbges.de
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| pubmed:publicationType |
Journal Article,
Case Reports
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