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rdf:type |
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lifeskim:mentions |
umls-concept:C0021149,
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0029445,
umls-concept:C0040053,
umls-concept:C0205314,
umls-concept:C0392756,
umls-concept:C0679622,
umls-concept:C1328819,
umls-concept:C1512045,
umls-concept:C1567768
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pubmed:issue |
2
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pubmed:dateCreated |
2009-1-26
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pubmed:abstractText |
Intravascular-thrombosis and extravascular-lipid-deposition are the two key pathogenic events considered to interrupt intraosseous blood supply during steroid-associated osteonecrosis (ON) development. However, there are no reported candidate agents capable of simultaneously targeting these two key pathogenic events. The authors' published experimental studies have shown that Epimedium-derived flavonoids possess an anti-ON effect. Further, the authors have recently identified a small molecule Icaritin as an intestinal metabolite of Epimedium-derived flavonoids.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1873-2763
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pubmed:author |
pubmed-author:GriffithJames FJF,
pubmed-author:LeeKwong-ManKM,
pubmed-author:LeungKwok-SuiKS,
pubmed-author:LiZi-RongZR,
pubmed-author:PenaC ECE,
pubmed-author:ShengHuiH,
pubmed-author:WangXin-LuanXL,
pubmed-author:WangYi-XiangYX,
pubmed-author:XieXin-HuiXH,
pubmed-author:YaoXin-ShengXS,
pubmed-author:YeungDavid Ka-WaiDK,
pubmed-author:ZhangGeG
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pubmed:issnType |
Electronic
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pubmed:volume |
44
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
345-56
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pubmed:meshHeading |
pubmed-meshheading:19015051-Angiography,
pubmed-meshheading:19015051-Animals,
pubmed-meshheading:19015051-Blood Vessels,
pubmed-meshheading:19015051-Dose-Response Relationship, Drug,
pubmed-meshheading:19015051-Flavonoids,
pubmed-meshheading:19015051-Lipid Metabolism,
pubmed-meshheading:19015051-Magnetic Resonance Imaging,
pubmed-meshheading:19015051-Male,
pubmed-meshheading:19015051-Osteonecrosis,
pubmed-meshheading:19015051-Particle Size,
pubmed-meshheading:19015051-Perfusion,
pubmed-meshheading:19015051-Rabbits,
pubmed-meshheading:19015051-Steroids,
pubmed-meshheading:19015051-Thrombosis,
pubmed-meshheading:19015051-Treatment Outcome,
pubmed-meshheading:19015051-Vascular Endothelial Growth Factor A,
pubmed-meshheading:19015051-X-Ray Microtomography
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pubmed:year |
2009
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pubmed:articleTitle |
A novel semisynthesized small molecule icaritin reduces incidence of steroid-associated osteonecrosis with inhibition of both thrombosis and lipid-deposition in a dose-dependent manner.
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pubmed:affiliation |
Musculoskeletal Research Laboratory, Department of Orthopaedics & Traumatology, the Chinese University of Hong Kong, Shatin, N.T. Hong Kong SAR.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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