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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
23
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pubmed:dateCreated |
2009-2-20
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pubmed:abstractText |
A weak, nonselective G protein-coupled receptor 120 (GPR120) agonist 10 was found by screening a series of carboxylic acids derived from the peroxisome proliferator-activated receptor gamma (PPARgamma) agonist 3. Modification based on the homology model of GPR120 led to the first GPR120-selective agonist 12. These results provide a basis for constructing new tools for probing the biology of GPR120 and for developing new candidate therapeutic agents.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1520-4804
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pubmed:author |
pubmed-author:FujiedaHirokiH,
pubmed-author:HataMieM,
pubmed-author:HiranoTatsuyaT,
pubmed-author:HirasawaAkiraA,
pubmed-author:IgariSou-IchiS,
pubmed-author:IshiguroMasajiM,
pubmed-author:ItohYukihiroY,
pubmed-author:MakishimaMakotoM,
pubmed-author:MiyataNaokiN,
pubmed-author:NakagawaHidehikoH,
pubmed-author:OguraMichitakaM,
pubmed-author:SuzukiTakayoshiT,
pubmed-author:TsujimotoGozohG
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pubmed:issnType |
Electronic
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pubmed:day |
11
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pubmed:volume |
51
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
7640-4
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pubmed:dateRevised |
2011-11-3
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pubmed:meshHeading |
pubmed-meshheading:19007110-Binding Sites,
pubmed-meshheading:19007110-Carboxylic Acids,
pubmed-meshheading:19007110-Crystallography, X-Ray,
pubmed-meshheading:19007110-Dose-Response Relationship, Drug,
pubmed-meshheading:19007110-Drug Design,
pubmed-meshheading:19007110-Humans,
pubmed-meshheading:19007110-Hydrogen Bonding,
pubmed-meshheading:19007110-Models, Molecular,
pubmed-meshheading:19007110-Molecular Structure,
pubmed-meshheading:19007110-PPAR gamma,
pubmed-meshheading:19007110-Receptors, G-Protein-Coupled,
pubmed-meshheading:19007110-Stereoisomerism,
pubmed-meshheading:19007110-Structure-Activity Relationship
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pubmed:year |
2008
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pubmed:articleTitle |
Identification of G protein-coupled receptor 120-selective agonists derived from PPARgamma agonists.
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pubmed:affiliation |
Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, Aichi 467-8603, Japan.
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pubmed:publicationType |
Journal Article
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