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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1991-4-17
|
| pubmed:abstractText |
Brain fast transient K+ channel (A channel) is known to be modulated by PKC activation. We studied, by two-electrode voltage clamp, the molecular mechanism of modulation by PKC activation of A-channels expressed in Xenopus oocytes from the Shaker H4 clone. The modulation is inhibitory affecting primarily the maximal conductance of the channels. A secondary effect is a small change in the voltage-dependence of activation and inactivation of the channel.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0014-5793
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
25
|
| pubmed:volume |
279
|
| pubmed:geneSymbol |
Shaker
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
256-60
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:1900473-Animals,
pubmed-meshheading:1900473-Drosophila melanogaster,
pubmed-meshheading:1900473-Electric Conductivity,
pubmed-meshheading:1900473-Enzyme Activation,
pubmed-meshheading:1900473-Membrane Potentials,
pubmed-meshheading:1900473-Potassium Channels,
pubmed-meshheading:1900473-Protein Kinase C,
pubmed-meshheading:1900473-Recombinant Proteins,
pubmed-meshheading:1900473-Tetradecanoylphorbol Acetate
|
| pubmed:year |
1991
|
| pubmed:articleTitle |
Modulation of a Shaker potassium A-channel by protein kinase C activation.
|
| pubmed:affiliation |
Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|