| pubmed-article:1900243 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1900243 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:1900243 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:1900243 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:1900243 | lifeskim:mentions | umls-concept:C0926407 | lld:lifeskim |
| pubmed-article:1900243 | lifeskim:mentions | umls-concept:C0021027 | lld:lifeskim |
| pubmed-article:1900243 | lifeskim:mentions | umls-concept:C0021036 | lld:lifeskim |
| pubmed-article:1900243 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:1900243 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:1900243 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:1900243 | lifeskim:mentions | umls-concept:C1519595 | lld:lifeskim |
| pubmed-article:1900243 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:1900243 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:1900243 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:1900243 | pubmed:dateCreated | 1991-4-8 | lld:pubmed |
| pubmed-article:1900243 | pubmed:abstractText | Ordered rearrangement of immunoglobulin genes (heavy chain then kappa and eventually lambda genes) is observed during B lymphocyte ontogeny. Unexpectedly, we found that human mature B cells producing kappa chains and having germ-line lambda genes contain lambda mRNA consisting of an invariant 5' region (herein termed X) and of one of the classical C lambda exons. The X region of these transcripts originates from a unique exon located 5 kb upstream of the J-C lambda 1 gene segment. X-C lambda mRNA expression occurs without somatic DNA rearrangement. The use of the X DNA fragment as a probe allows definition of a family of human genes that comprises at least four members and includes the first exon of the lambda 14.1 gene. The latter is selectively transcribed in pre-B lymphocytes and directs the synthesis of a lambda-like chain. In contrast, the X-C lambda transcripts do not appear to encode a C lambda-related polypeptide in mature B cells. Thus, despite a 73% homology extending far beyond the exon sequences, the X and lambda 14.1 genes are expressed at different stages of B cell development and might serve different functions. | lld:pubmed |
| pubmed-article:1900243 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1900243 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1900243 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1900243 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1900243 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1900243 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1900243 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1900243 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:1900243 | pubmed:issn | 0014-2980 | lld:pubmed |
| pubmed-article:1900243 | pubmed:author | pubmed-author:GuglielmiPP | lld:pubmed |
| pubmed-article:1900243 | pubmed:author | pubmed-author:DaviFF | lld:pubmed |
| pubmed-article:1900243 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1900243 | pubmed:volume | 21 | lld:pubmed |
| pubmed-article:1900243 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1900243 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1900243 | pubmed:pagination | 501-8 | lld:pubmed |
| pubmed-article:1900243 | pubmed:dateRevised | 2005-11-17 | lld:pubmed |
| pubmed-article:1900243 | pubmed:meshHeading | pubmed-meshheading:1900243-... | lld:pubmed |
| pubmed-article:1900243 | pubmed:meshHeading | pubmed-meshheading:1900243-... | lld:pubmed |
| pubmed-article:1900243 | pubmed:meshHeading | pubmed-meshheading:1900243-... | lld:pubmed |
| pubmed-article:1900243 | pubmed:meshHeading | pubmed-meshheading:1900243-... | lld:pubmed |
| pubmed-article:1900243 | pubmed:meshHeading | pubmed-meshheading:1900243-... | lld:pubmed |
| pubmed-article:1900243 | pubmed:meshHeading | pubmed-meshheading:1900243-... | lld:pubmed |
| pubmed-article:1900243 | pubmed:meshHeading | pubmed-meshheading:1900243-... | lld:pubmed |
| pubmed-article:1900243 | pubmed:meshHeading | pubmed-meshheading:1900243-... | lld:pubmed |
| pubmed-article:1900243 | pubmed:meshHeading | pubmed-meshheading:1900243-... | lld:pubmed |
| pubmed-article:1900243 | pubmed:meshHeading | pubmed-meshheading:1900243-... | lld:pubmed |
| pubmed-article:1900243 | pubmed:meshHeading | pubmed-meshheading:1900243-... | lld:pubmed |
| pubmed-article:1900243 | pubmed:meshHeading | pubmed-meshheading:1900243-... | lld:pubmed |
| pubmed-article:1900243 | pubmed:meshHeading | pubmed-meshheading:1900243-... | lld:pubmed |
| pubmed-article:1900243 | pubmed:meshHeading | pubmed-meshheading:1900243-... | lld:pubmed |
| pubmed-article:1900243 | pubmed:meshHeading | pubmed-meshheading:1900243-... | lld:pubmed |
| pubmed-article:1900243 | pubmed:meshHeading | pubmed-meshheading:1900243-... | lld:pubmed |
| pubmed-article:1900243 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1900243 | pubmed:articleTitle | Expression of a novel type of immunoglobulin C lambda transcripts in human mature B lymphocytes producing kappa light chains. | lld:pubmed |
| pubmed-article:1900243 | pubmed:affiliation | Institut National de la Santé et de la Recherche Médicale, Hôpital Saint Louis, Paris, France. | lld:pubmed |
| pubmed-article:1900243 | pubmed:publicationType | Journal Article | lld:pubmed |
| entrez-gene:100423062 | entrezgene:pubmed | pubmed-article:1900243 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1900243 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1900243 | lld:pubmed |
