| pubmed-article:19000740 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19000740 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:19000740 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:19000740 | lifeskim:mentions | umls-concept:C0027819 | lld:lifeskim |
| pubmed-article:19000740 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:19000740 | lifeskim:mentions | umls-concept:C0000098 | lld:lifeskim |
| pubmed-article:19000740 | lifeskim:mentions | umls-concept:C0069389 | lld:lifeskim |
| pubmed-article:19000740 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:19000740 | pubmed:dateCreated | 2008-12-8 | lld:pubmed |
| pubmed-article:19000740 | pubmed:abstractText | 1-methyl-4-phenylpyridinium ion (MPP(+)) has been shown to selectively inhibit mitochondrial function and induce a parkinsonism-like syndrome. MPP(+) stimulates the production of reactive oxygen species (ROS) and induces cell death in vitro. In this study, we investigated the protective effects of okadaic acid on MPP(+)-induced cell death in SH-SY5Y neuroblastoma cells. We found that MPP(+)-induced apoptosis and -ROS generation were blocked by okadaic acid. MPP(+)-mediated activation of AKT was also inhibited by okadaic acid. Taken together, these results demonstrate that okadaic acid protects against MPP(+)-induced apoptosis by blocking ROS stimulation and ROS-mediated signaling pathways in SH-SY5Y cells. These data indicated that okadaic acid could provide a therapeutic strategy for the treatment of neurodegenerative diseases including Parkinson's disease. | lld:pubmed |
| pubmed-article:19000740 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19000740 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19000740 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19000740 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19000740 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19000740 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19000740 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19000740 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19000740 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19000740 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19000740 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19000740 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19000740 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:19000740 | pubmed:issn | 0304-3940 | lld:pubmed |
| pubmed-article:19000740 | pubmed:author | pubmed-author:JeongJoo-WonJ... | lld:pubmed |
| pubmed-article:19000740 | pubmed:author | pubmed-author:ParkChanC | lld:pubmed |
| pubmed-article:19000740 | pubmed:author | pubmed-author:HuhYoungbuhmY | lld:pubmed |
| pubmed-article:19000740 | pubmed:author | pubmed-author:KimYoung-SunY... | lld:pubmed |
| pubmed-article:19000740 | pubmed:author | pubmed-author:AhnKook-HeeKH | lld:pubmed |
| pubmed-article:19000740 | pubmed:author | pubmed-author:KimSeon-YeSY | lld:pubmed |
| pubmed-article:19000740 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:19000740 | pubmed:day | 9 | lld:pubmed |
| pubmed-article:19000740 | pubmed:volume | 449 | lld:pubmed |
| pubmed-article:19000740 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19000740 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19000740 | pubmed:pagination | 93-7 | lld:pubmed |
| pubmed-article:19000740 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:19000740 | pubmed:meshHeading | pubmed-meshheading:19000740... | lld:pubmed |
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| pubmed-article:19000740 | pubmed:meshHeading | pubmed-meshheading:19000740... | lld:pubmed |
| pubmed-article:19000740 | pubmed:meshHeading | pubmed-meshheading:19000740... | lld:pubmed |
| pubmed-article:19000740 | pubmed:meshHeading | pubmed-meshheading:19000740... | lld:pubmed |
| pubmed-article:19000740 | pubmed:meshHeading | pubmed-meshheading:19000740... | lld:pubmed |
| pubmed-article:19000740 | pubmed:meshHeading | pubmed-meshheading:19000740... | lld:pubmed |
| pubmed-article:19000740 | pubmed:meshHeading | pubmed-meshheading:19000740... | lld:pubmed |
| pubmed-article:19000740 | pubmed:meshHeading | pubmed-meshheading:19000740... | lld:pubmed |
| pubmed-article:19000740 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19000740 | pubmed:articleTitle | Okadaic acid protects human neuroblastoma SH-SY5Y cells from 1-methyl-4-phenylpyridinium ion-induced apoptosis. | lld:pubmed |
| pubmed-article:19000740 | pubmed:affiliation | Department of Anatomy and Neurobiology, Biomedical Science Institute, School of Medicine, Kyung Hee University, Seoul, Republic of Korea. | lld:pubmed |
| pubmed-article:19000740 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19000740 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
