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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2008-12-8
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pubmed:abstractText |
1-methyl-4-phenylpyridinium ion (MPP(+)) has been shown to selectively inhibit mitochondrial function and induce a parkinsonism-like syndrome. MPP(+) stimulates the production of reactive oxygen species (ROS) and induces cell death in vitro. In this study, we investigated the protective effects of okadaic acid on MPP(+)-induced cell death in SH-SY5Y neuroblastoma cells. We found that MPP(+)-induced apoptosis and -ROS generation were blocked by okadaic acid. MPP(+)-mediated activation of AKT was also inhibited by okadaic acid. Taken together, these results demonstrate that okadaic acid protects against MPP(+)-induced apoptosis by blocking ROS stimulation and ROS-mediated signaling pathways in SH-SY5Y cells. These data indicated that okadaic acid could provide a therapeutic strategy for the treatment of neurodegenerative diseases including Parkinson's disease.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0304-3940
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
9
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pubmed:volume |
449
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
93-7
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:19000740-1-Methyl-4-phenylpyridinium,
pubmed-meshheading:19000740-Apoptosis,
pubmed-meshheading:19000740-Cell Line, Tumor,
pubmed-meshheading:19000740-Cytoprotection,
pubmed-meshheading:19000740-Enzyme Inhibitors,
pubmed-meshheading:19000740-Herbicides,
pubmed-meshheading:19000740-Humans,
pubmed-meshheading:19000740-Nerve Degeneration,
pubmed-meshheading:19000740-Neuroblastoma,
pubmed-meshheading:19000740-Neurons,
pubmed-meshheading:19000740-Neuroprotective Agents,
pubmed-meshheading:19000740-Okadaic Acid,
pubmed-meshheading:19000740-Oxidative Stress,
pubmed-meshheading:19000740-Parkinson Disease,
pubmed-meshheading:19000740-Protein Phosphatase 2,
pubmed-meshheading:19000740-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:19000740-Reactive Oxygen Species,
pubmed-meshheading:19000740-Signal Transduction
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pubmed:year |
2009
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pubmed:articleTitle |
Okadaic acid protects human neuroblastoma SH-SY5Y cells from 1-methyl-4-phenylpyridinium ion-induced apoptosis.
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pubmed:affiliation |
Department of Anatomy and Neurobiology, Biomedical Science Institute, School of Medicine, Kyung Hee University, Seoul, Republic of Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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