Source:http://linkedlifedata.com/resource/pubmed/id/18996151
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2009-1-27
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| pubmed:abstractText |
The purinergic P2X(7) receptor is a ligand-gated ion channel found on peripheral macrophages and microglia in the nervous system. Activation of P2X(7) receptors results in the rapid release of interleukin-1 beta (IL-1 beta). Cytokines like IL-1 beta are suggested to be involved in the pathophysiology of depression. The aim of this study was to behaviorally profile P2X(7) receptor knockout (KO) mice in behavioral models of depression- and anxiety-like behaviors. P2X(7) receptor KO and wild type (WT) mice were tested in multiple models including; forced swim test, tail suspension test, elevated plus maze, novelty suppressed feeding, spontaneous locomotor activity, and food intake. P2X(7) receptor KO mice exhibited an antidepressant-like profile in tail suspension test and forced swim test; an effect that was not associated with changes in spontaneous locomotor activity. In addition, P2X(7) receptor KO mice showed higher responsivity to a subefficacious dose of the antidepressant drug imipramine (15 mg/kg) in forced swim test. No significant differences between genotypes were observed in models of anxiety. These data support the relevance of pro-inflammatory cytokines in depressive-like states, and suggest that P2X(7) receptor antagonists could be of potential interest for the treatment of affective disorders.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Mar
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| pubmed:issn |
1872-7549
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:day |
2
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| pubmed:volume |
198
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
83-90
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| pubmed:meshHeading |
pubmed-meshheading:18996151-Analysis of Variance,
pubmed-meshheading:18996151-Animals,
pubmed-meshheading:18996151-Antidepressive Agents, Tricyclic,
pubmed-meshheading:18996151-Anxiety,
pubmed-meshheading:18996151-Behavior, Animal,
pubmed-meshheading:18996151-Depression,
pubmed-meshheading:18996151-Disease Models, Animal,
pubmed-meshheading:18996151-Eating,
pubmed-meshheading:18996151-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:18996151-Exploratory Behavior,
pubmed-meshheading:18996151-Hindlimb Suspension,
pubmed-meshheading:18996151-Imipramine,
pubmed-meshheading:18996151-Interleukin-1beta,
pubmed-meshheading:18996151-Male,
pubmed-meshheading:18996151-Maze Learning,
pubmed-meshheading:18996151-Mice,
pubmed-meshheading:18996151-Mice, Inbred C57BL,
pubmed-meshheading:18996151-Mice, Knockout,
pubmed-meshheading:18996151-Motor Activity,
pubmed-meshheading:18996151-Polymerase Chain Reaction,
pubmed-meshheading:18996151-Receptors, Purinergic P2,
pubmed-meshheading:18996151-Swimming
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| pubmed:year |
2009
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| pubmed:articleTitle |
Behavioral profile of P2X7 receptor knockout mice in animal models of depression and anxiety: relevance for neuropsychiatric disorders.
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| pubmed:affiliation |
Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA. Ana.basso@abbott.com
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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