Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
26
pubmed:dateCreated
2008-11-10
pubmed:abstractText
Red wine represents a source of polyphenols which exhibit a number of biological effects on various systems. In this respect, there is evidence that red wine polyphenols constitute one of the ingredients of the Mediterranean diet which is associated to a reduced risk of coronary heart disease according to current literature. Here, we have evaluated in vitro the molecular mechanisms elicited by polyphenols from red wine (Negroamaro) on human healthy mononuclear cells. In particular, we have investigated the involvement of polyphenols in the activation of p38 and ERK1/2 molecules belonging to the MAPK kinase family and on the expression of I kappaB alpha and p65/NF kappaB. Results will demonstrate that in cells both the expression of p38 and ERK1/2 augments in the presence of red wine polyphenols, but their expression drops in the presence of polyphenols plus lipopolysaccharides (LPS). This indicates that in Gram-negative infections polyphenols may attenuate triggering of inflammatory mediators as a response to LPS stimulation. Finally, the regulatory role of polyphenols on I kappaB alpha and p65/NF kappaB expression is discussed, pointing out that red wine might favor anti-atherogenic mechanisms in the course of cardiovascular disease.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Flavonoids, http://linkedlifedata.com/resource/pubmed/chemical/I-kappa B Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Inflammation Mediators, http://linkedlifedata.com/resource/pubmed/chemical/Lipopolysaccharides, http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 1, http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 3, http://linkedlifedata.com/resource/pubmed/chemical/NF-kappaB inhibitor alpha, http://linkedlifedata.com/resource/pubmed/chemical/Phenols, http://linkedlifedata.com/resource/pubmed/chemical/Polyphenols, http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factor RelA, http://linkedlifedata.com/resource/pubmed/chemical/p38 Mitogen-Activated Protein...
pubmed:status
MEDLINE
pubmed:issn
1873-4286
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2758-66
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:18991694-Bacterial Infections, pubmed-meshheading:18991694-Cardiovascular Diseases, pubmed-meshheading:18991694-Chronic Disease, pubmed-meshheading:18991694-Diet, pubmed-meshheading:18991694-Flavonoids, pubmed-meshheading:18991694-Gene Expression Regulation, pubmed-meshheading:18991694-Humans, pubmed-meshheading:18991694-I-kappa B Proteins, pubmed-meshheading:18991694-Inflammation Mediators, pubmed-meshheading:18991694-Leukocytes, Mononuclear, pubmed-meshheading:18991694-Lipopolysaccharides, pubmed-meshheading:18991694-Mitogen-Activated Protein Kinase 1, pubmed-meshheading:18991694-Mitogen-Activated Protein Kinase 3, pubmed-meshheading:18991694-Phenols, pubmed-meshheading:18991694-Polyphenols, pubmed-meshheading:18991694-Transcription Factor RelA, pubmed-meshheading:18991694-Wine, pubmed-meshheading:18991694-p38 Mitogen-Activated Protein Kinases
pubmed:year
2008
pubmed:articleTitle
Molecular effects elicited in vitro by red wine on human healthy peripheral blood mononuclear cells: potential therapeutical application of polyphenols to diet-related chronic diseases.
pubmed:affiliation
Immunology, University of Bari, Piazza G. Cesare 11, 70124, Bari, Italy.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't