| pubmed-article:18984862 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18984862 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:18984862 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:18984862 | lifeskim:mentions | umls-concept:C0085669 | lld:lifeskim |
| pubmed-article:18984862 | lifeskim:mentions | umls-concept:C1235660 | lld:lifeskim |
| pubmed-article:18984862 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:18984862 | lifeskim:mentions | umls-concept:C1704735 | lld:lifeskim |
| pubmed-article:18984862 | lifeskim:mentions | umls-concept:C1554080 | lld:lifeskim |
| pubmed-article:18984862 | lifeskim:mentions | umls-concept:C1706198 | lld:lifeskim |
| pubmed-article:18984862 | lifeskim:mentions | umls-concept:C1998548 | lld:lifeskim |
| pubmed-article:18984862 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:18984862 | pubmed:dateCreated | 2009-2-20 | lld:pubmed |
| pubmed-article:18984862 | pubmed:abstractText | Understanding the pathways that regulate the human T-cell acute lymphoblastic leukemia (T-ALL) initiating cells (T-LiC) activity has been hampered by the lack of biologic assays in which this human disease can be studied. Here we show that coculture of primary human T-ALL with a mouse stromal cell line expressing the NOTCH ligand delta-like-1 (DL1) reproducibly allowed maintenance of T-LiC and long-term growth of blast cells. Human T-ALL mutated or not on the NOTCH receptor required sustained activation of the NOTCH pathway via receptor/ligand interaction for growth and T-LiC activity. On the reverse, inhibition of the NOTCH pathway during primary cultures abolished in vitro cell growth and in vivo T-LiC activity. Altogether, these results demonstrate the major role of the NOTCH pathway activation in human T-ALL development and in the maintenance of leukemia-initiating cells. | lld:pubmed |
| pubmed-article:18984862 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18984862 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18984862 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:18984862 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18984862 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18984862 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18984862 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18984862 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18984862 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18984862 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18984862 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18984862 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18984862 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:18984862 | pubmed:issn | 1528-0020 | lld:pubmed |
| pubmed-article:18984862 | pubmed:author | pubmed-author:BalleriniPaol... | lld:pubmed |
| pubmed-article:18984862 | pubmed:author | pubmed-author:RoméoPaul-Hen... | lld:pubmed |
| pubmed-article:18984862 | pubmed:author | pubmed-author:DombretHervéH | lld:pubmed |
| pubmed-article:18984862 | pubmed:author | pubmed-author:Brunet de... | lld:pubmed |
| pubmed-article:18984862 | pubmed:author | pubmed-author:BaruchelAndré... | lld:pubmed |
| pubmed-article:18984862 | pubmed:author | pubmed-author:PflumioFranço... | lld:pubmed |
| pubmed-article:18984862 | pubmed:author | pubmed-author:Landman-Parke... | lld:pubmed |
| pubmed-article:18984862 | pubmed:author | pubmed-author:BoisselNicola... | lld:pubmed |
| pubmed-article:18984862 | pubmed:author | pubmed-author:ArmstrongFlor... | lld:pubmed |
| pubmed-article:18984862 | pubmed:author | pubmed-author:RouyezMarie-C... | lld:pubmed |
| pubmed-article:18984862 | pubmed:author | pubmed-author:GerbyBastienB | lld:pubmed |
| pubmed-article:18984862 | pubmed:author | pubmed-author:CalvoJulienJ | lld:pubmed |
| pubmed-article:18984862 | pubmed:author | pubmed-author:FontenayMicha... | lld:pubmed |
| pubmed-article:18984862 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18984862 | pubmed:day | 19 | lld:pubmed |
| pubmed-article:18984862 | pubmed:volume | 113 | lld:pubmed |
| pubmed-article:18984862 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18984862 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18984862 | pubmed:pagination | 1730-40 | lld:pubmed |
| pubmed-article:18984862 | pubmed:dateRevised | 2009-6-26 | lld:pubmed |
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| pubmed-article:18984862 | pubmed:meshHeading | pubmed-meshheading:18984862... | lld:pubmed |
| pubmed-article:18984862 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:18984862 | pubmed:articleTitle | NOTCH is a key regulator of human T-cell acute leukemia initiating cell activity. | lld:pubmed |
| pubmed-article:18984862 | pubmed:affiliation | Institut Cochin, Université Paris Descartes, Centre National de la Recherche Scientifique, Unite Mixte de Recherche 8104 Paris, France. | lld:pubmed |
| pubmed-article:18984862 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18984862 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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