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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2008-12-22
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pubmed:abstractText |
Klebsiella pneumoniae is a leading cause of both community-acquired and nosocomial gram-negative bacterial pneumonia. A significant clinical complication of Klebsiella pulmonary infections is peripheral blood dissemination, resulting in a systemic infection concurrent with the localized pulmonary infection. We report here on the critical importance of beta(2)-microglobulin expression during murine K. pneumoniae bacteremia. Beta(2)-microglobulin knockout mice displayed significantly increased mortality upon intravenous inoculation that correlated with increased bacterial burden in the blood, liver, and spleen. As beta(2)-microglobulin knockout mice lack both CD8(+) T cells and invariant NK T cells, mouse models specifically deficient in either cell population were examined to see if this would account for the increased mortality noted in beta(2)-microglobulin knockout mice. Surprisingly, neither CD8 T-cell-deficient (TAP-1 knockout; in vivo anti-CD8 antibody treatment) nor invariant NK (iNK) T-cell-deficient (CD1d knockout, J alpha281 knockout) mice were more susceptible to K. pneumoniae bacteremia. Combined, these studies clearly indicate the importance of a beta(2)-microglobulin-dependent but CD8 T-cell- and iNK T-cell-independent mechanism critical for survival during K. pneumoniae bacteremia.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18981251-10476722,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18981251-10557317,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18981251-10618487,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18981251-10695657,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18981251-10760288,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18981251-10837074,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18981251-10919985,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18981251-10946293,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18981251-11260522,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18981251-11309710,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18981251-11470769,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18981251-11729128,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18981251-11773612,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18981251-11972873,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18981251-12133968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18981251-12379710,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18981251-12461085,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18981251-12543936,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18981251-12626348,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18981251-12933830,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18981251-14501943,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18981251-1465432,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18981251-15189741,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18981251-15963710,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18981251-16841095,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18981251-16849638,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18981251-8643606,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18981251-8643666,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18981251-8920884,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18981251-9014824,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18981251-9482913,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18981251-9767057
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1098-5522
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
77
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
360-6
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:18981251-Animals,
pubmed-meshheading:18981251-Bacteremia,
pubmed-meshheading:18981251-Blood,
pubmed-meshheading:18981251-CD8-Positive T-Lymphocytes,
pubmed-meshheading:18981251-Colony Count, Microbial,
pubmed-meshheading:18981251-Killer Cells, Natural,
pubmed-meshheading:18981251-Klebsiella pneumoniae,
pubmed-meshheading:18981251-Liver,
pubmed-meshheading:18981251-Mice,
pubmed-meshheading:18981251-Mice, Inbred C57BL,
pubmed-meshheading:18981251-Mice, Knockout,
pubmed-meshheading:18981251-Spleen,
pubmed-meshheading:18981251-Survival Analysis,
pubmed-meshheading:18981251-beta 2-Microglobulin
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pubmed:year |
2009
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pubmed:articleTitle |
Beta2-microglobulin-dependent bacterial clearance and survival during murine Klebsiella pneumoniae bacteremia.
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pubmed:affiliation |
Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109-0642, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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