| pubmed-article:18981247 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18981247 | lifeskim:mentions | umls-concept:C1136253 | lld:lifeskim |
| pubmed-article:18981247 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:18981247 | lifeskim:mentions | umls-concept:C0014834 | lld:lifeskim |
| pubmed-article:18981247 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:18981247 | lifeskim:mentions | umls-concept:C1416522 | lld:lifeskim |
| pubmed-article:18981247 | lifeskim:mentions | umls-concept:C0180979 | lld:lifeskim |
| pubmed-article:18981247 | lifeskim:mentions | umls-concept:C0450254 | lld:lifeskim |
| pubmed-article:18981247 | lifeskim:mentions | umls-concept:C0082180 | lld:lifeskim |
| pubmed-article:18981247 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:18981247 | pubmed:dateCreated | 2008-12-22 | lld:pubmed |
| pubmed-article:18981247 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18981247 | pubmed:abstractText | Five types of cytolethal distending toxin (CDT-I to CDT-V) have been identified in Escherichia coli. In the present study we cloned and sequenced the cdt-IV operon and flanking region from a porcine extraintestinal pathogenic E. coli (ExPEC) strain belonging to serogroup O75. We confirmed that similar to other CDTs, CDT-IV induced phosphorylation of host histone H2AX, a sensitive marker of DNA double-strand breaks, and blocked the HeLa cell cycle at the G(2)-M transition. The cdt-IV genes were framed by lambdoid prophage genes. We cloned and sequenced the cdt-I operon and flanking regions from a human ExPEC O18:K1:H7 strain and observed that cdt-I genes were also flanked by lambdoid prophage genes. PCR studies indicated that a gene coding for a putative protease was always associated with the cdtC-IV gene but was not associated with cdtC genes in strains producing CDT-I, CDT-III, and CDT-V. Our results suggest that the cdt-I and cdt-IV genes might have been acquired from a common ancestor by phage transduction and evolved in their bacterial hosts. The lysogenic bacteriophages have the potential to carry nonessential "cargo" genes or "morons" and therefore play a crucial role in the generation of genetic diversity within ExPEC. | lld:pubmed |
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| pubmed-article:18981247 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18981247 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18981247 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18981247 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18981247 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18981247 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18981247 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18981247 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:18981247 | pubmed:issn | 1098-5522 | lld:pubmed |
| pubmed-article:18981247 | pubmed:author | pubmed-author:FujiwaraTamak... | lld:pubmed |
| pubmed-article:18981247 | pubmed:author | pubmed-author:SugaiMotoyuki... | lld:pubmed |
| pubmed-article:18981247 | pubmed:author | pubmed-author:DobrindtUlric... | lld:pubmed |
| pubmed-article:18981247 | pubmed:author | pubmed-author:OswaldEricE | lld:pubmed |
| pubmed-article:18981247 | pubmed:author | pubmed-author:HackerJörgJ | lld:pubmed |
| pubmed-article:18981247 | pubmed:author | pubmed-author:LedgerTerence... | lld:pubmed |
| pubmed-article:18981247 | pubmed:author | pubmed-author:MorabitoStefa... | lld:pubmed |
| pubmed-article:18981247 | pubmed:author | pubmed-author:NougayrèdeJea... | lld:pubmed |
| pubmed-article:18981247 | pubmed:author | pubmed-author:BouryMichèleM | lld:pubmed |
| pubmed-article:18981247 | pubmed:author | pubmed-author:TóthIstvánI | lld:pubmed |
| pubmed-article:18981247 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18981247 | pubmed:volume | 77 | lld:pubmed |
| pubmed-article:18981247 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18981247 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18981247 | pubmed:pagination | 492-500 | lld:pubmed |
| pubmed-article:18981247 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:18981247 | pubmed:meshHeading | pubmed-meshheading:18981247... | lld:pubmed |
| pubmed-article:18981247 | pubmed:meshHeading | pubmed-meshheading:18981247... | lld:pubmed |
| pubmed-article:18981247 | pubmed:meshHeading | pubmed-meshheading:18981247... | lld:pubmed |
| pubmed-article:18981247 | pubmed:meshHeading | pubmed-meshheading:18981247... | lld:pubmed |
| pubmed-article:18981247 | pubmed:meshHeading | pubmed-meshheading:18981247... | lld:pubmed |
| pubmed-article:18981247 | pubmed:meshHeading | pubmed-meshheading:18981247... | lld:pubmed |
| pubmed-article:18981247 | pubmed:meshHeading | pubmed-meshheading:18981247... | lld:pubmed |
| pubmed-article:18981247 | pubmed:meshHeading | pubmed-meshheading:18981247... | lld:pubmed |
| pubmed-article:18981247 | pubmed:meshHeading | pubmed-meshheading:18981247... | lld:pubmed |
| pubmed-article:18981247 | pubmed:meshHeading | pubmed-meshheading:18981247... | lld:pubmed |
| pubmed-article:18981247 | pubmed:meshHeading | pubmed-meshheading:18981247... | lld:pubmed |
| pubmed-article:18981247 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:18981247 | pubmed:articleTitle | Cytolethal distending toxin type I and type IV genes are framed with lambdoid prophage genes in extraintestinal pathogenic Escherichia coli. | lld:pubmed |
| pubmed-article:18981247 | pubmed:affiliation | Veterinary Medical Research Institute of the Hungarian Academy of Sciences, Budapest, Hungary. Tothi@vmri.hu | lld:pubmed |
| pubmed-article:18981247 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18981247 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
