|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5
|
|
pubmed:dateCreated |
2008-11-3
|
|
pubmed:abstractText |
Studies support the importance of microRNAs in physiological and pathological processes. Here we describe the regulation and function of miR-29 in myogenesis and rhabdomyosarcoma (RMS). Results demonstrate that in myoblasts, miR-29 is repressed by NF-kappaB acting through YY1 and the Polycomb group. During myogenesis, NF-kappaB and YY1 downregulation causes derepression of miR-29, which in turn accelerates differentiation by targeting its repressor YY1. However, in RMS cells and primary tumors that possess impaired differentiation, miR-29 is epigenetically silenced by an activated NF-kappaB-YY1 pathway. Reconstitution of miR-29 in RMS in mice inhibits tumor growth and stimulates differentiation, suggesting that miR-29 acts as a tumor suppressor through its promyogenic function. Together, these results identify a NF-kappaB-YY1-miR-29 regulatory circuit whose disruption may contribute to RMS.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Nov
|
|
pubmed:issn |
1878-3686
|
|
pubmed:author |
pubmed-author:ChandlerDawn SDS,
pubmed-author:ChengAlfredA,
pubmed-author:CroceCarlo MCM,
pubmed-author:DahlmanJasonJ,
pubmed-author:GarzonRamiroR,
pubmed-author:GuttridgeDenis CDC,
pubmed-author:HallBrett MBM,
pubmed-author:LadnerKatherine JKJ,
pubmed-author:QualmanStephen JSJ,
pubmed-author:SinghRaviR,
pubmed-author:SunHaoH,
pubmed-author:WangHuatingH
|
|
pubmed:issnType |
Electronic
|
|
pubmed:day |
4
|
|
pubmed:volume |
14
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
369-81
|
|
pubmed:dateRevised |
2011-9-22
|
|
pubmed:meshHeading |
pubmed-meshheading:18977326-Animals,
pubmed-meshheading:18977326-Blotting, Western,
pubmed-meshheading:18977326-Cell Cycle,
pubmed-meshheading:18977326-Cell Differentiation,
pubmed-meshheading:18977326-Cell Proliferation,
pubmed-meshheading:18977326-Cells, Cultured,
pubmed-meshheading:18977326-Chromatin Immunoprecipitation,
pubmed-meshheading:18977326-Computational Biology,
pubmed-meshheading:18977326-Down-Regulation,
pubmed-meshheading:18977326-Feedback, Physiological,
pubmed-meshheading:18977326-Fibroblasts,
pubmed-meshheading:18977326-Gene Expression Regulation, Developmental,
pubmed-meshheading:18977326-Humans,
pubmed-meshheading:18977326-Mice,
pubmed-meshheading:18977326-Mice, Inbred C57BL,
pubmed-meshheading:18977326-MicroRNAs,
pubmed-meshheading:18977326-Muscle Development,
pubmed-meshheading:18977326-Myoblasts, Skeletal,
pubmed-meshheading:18977326-NF-kappa B,
pubmed-meshheading:18977326-Nucleic Acid Conformation,
pubmed-meshheading:18977326-Promoter Regions, Genetic,
pubmed-meshheading:18977326-Rhabdomyosarcoma,
pubmed-meshheading:18977326-Signal Transduction,
pubmed-meshheading:18977326-YY1 Transcription Factor
|
|
pubmed:year |
2008
|
|
pubmed:articleTitle |
NF-kappaB-YY1-miR-29 regulatory circuitry in skeletal myogenesis and rhabdomyosarcoma.
|
|
pubmed:affiliation |
Department of Molecular Virology, Human Cancer Genetics Program, The Ohio State University, Columbus, OH 43210, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
|
