Source:http://linkedlifedata.com/resource/pubmed/id/18975262
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
15
|
| pubmed:dateCreated |
2008-12-16
|
| pubmed:abstractText |
Two new dimeric proanthocyanidins, ephedrannin B ( 2) and mahuannin E ( 4), along with two known congeners, ephedrannin A ( 1) and mahuannin D ( 3), were isolated from the roots of Ephedra sinica Stapf. Based on NMR, MS, and CD analysis, the structures of the new compounds were deduced to be 5,7,4'-trihydroxyflavan-[4(alpha)-->8,2(alpha)-->O-->7]-kaempferol ( 2) and 5,7,4'-trihydroxyflavan-[4(beta)-->8,2(beta)-->O-->7]- EPI-afzelechin ( 4). The compounds 1 - 4 were evaluated for cytotoxicity against three tumor cell lines (SGC-7901, HepG2, and HeLa), and 2 was found to be significantly active.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0032-0943
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
74
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1823-5
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| pubmed:meshHeading |
pubmed-meshheading:18975262-Antineoplastic Agents, Phytogenic,
pubmed-meshheading:18975262-Cell Line, Tumor,
pubmed-meshheading:18975262-Cytotoxins,
pubmed-meshheading:18975262-Drug Screening Assays, Antitumor,
pubmed-meshheading:18975262-Ephedra sinica,
pubmed-meshheading:18975262-Humans,
pubmed-meshheading:18975262-Magnetic Resonance Spectroscopy,
pubmed-meshheading:18975262-Plant Extracts,
pubmed-meshheading:18975262-Plant Roots,
pubmed-meshheading:18975262-Proanthocyanidins
|
| pubmed:year |
2008
|
| pubmed:articleTitle |
Dimeric proanthocyanidins from the roots of Ephedra sinica.
|
| pubmed:affiliation |
College of Chemistry, Jilin University, Changchun, P. R. China.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|