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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2009-4-6
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pubmed:abstractText |
Peroxisome proliferator-activated receptor-gamma (PPARgamma) ligands have been shown to possess potent anti-inflammatory actions. Idiopathic interstitial pneumonia is defined as a specific form of chronic fibrosing lung disease characterized by progressive fibrosis which leads to deterioration and destruction of the lungs. Objective: To investigate whether the PPARgamma ligand pioglitazone (PGZ) inhibited bleomycin (BLM)-induced acute lung injury and subsequent fibrosis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Bleomycin,
http://linkedlifedata.com/resource/pubmed/chemical/Collagen Type I,
http://linkedlifedata.com/resource/pubmed/chemical/Connective Tissue Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Ctgf protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Hypoglycemic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/PPAR gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Thiazolidinediones,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/pioglitazone
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pubmed:status |
MEDLINE
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pubmed:issn |
1423-0356
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pubmed:author |
pubmed-author:AokiFumiakiF,
pubmed-author:AokiNozomiN,
pubmed-author:AokiYasuhiroY,
pubmed-author:AoyagiKanaK,
pubmed-author:AraiMasashiM,
pubmed-author:KurabayashiMasahikoM,
pubmed-author:MaenoToshitakaT,
pubmed-author:NakagawaJunichiJ,
pubmed-author:SandoYoshichikaY,
pubmed-author:ShimizuYujiY,
pubmed-author:SugaTatsuoT,
pubmed-author:UenoManabuM
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pubmed:copyrightInfo |
Copyright 2008 S. Karger AG, Basel.
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pubmed:issnType |
Electronic
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pubmed:volume |
77
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
311-9
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pubmed:dateRevised |
2009-11-11
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pubmed:meshHeading |
pubmed-meshheading:18974632-Acute Lung Injury,
pubmed-meshheading:18974632-Animals,
pubmed-meshheading:18974632-Bleomycin,
pubmed-meshheading:18974632-Cells, Cultured,
pubmed-meshheading:18974632-Collagen Type I,
pubmed-meshheading:18974632-Connective Tissue Growth Factor,
pubmed-meshheading:18974632-Fibroblasts,
pubmed-meshheading:18974632-Fibrosis,
pubmed-meshheading:18974632-Humans,
pubmed-meshheading:18974632-Hypoglycemic Agents,
pubmed-meshheading:18974632-Lung,
pubmed-meshheading:18974632-Macrophages, Alveolar,
pubmed-meshheading:18974632-Male,
pubmed-meshheading:18974632-PPAR gamma,
pubmed-meshheading:18974632-Rats,
pubmed-meshheading:18974632-Rats, Wistar,
pubmed-meshheading:18974632-Thiazolidinediones,
pubmed-meshheading:18974632-Transforming Growth Factor beta,
pubmed-meshheading:18974632-Tumor Necrosis Factor-alpha
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pubmed:year |
2009
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pubmed:articleTitle |
Pioglitazone, a peroxisome proliferator-activated receptor gamma ligand, suppresses bleomycin-induced acute lung injury and fibrosis.
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pubmed:affiliation |
Department of Medicine and Biological Science, Gunma University Graduate School of Medicine, Maebashi, Japan. mkuraba@med.gunma-u.ac.jp
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pubmed:publicationType |
Journal Article
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