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rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0007634,
umls-concept:C0017262,
umls-concept:C0021920,
umls-concept:C0205214,
umls-concept:C0205419,
umls-concept:C0332281,
umls-concept:C0424540,
umls-concept:C0439662,
umls-concept:C0441889,
umls-concept:C0542478,
umls-concept:C1332822,
umls-concept:C1882417
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|
pubmed:issue |
6
|
|
pubmed:dateCreated |
2008-12-16
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|
pubmed:abstractText |
CXCR3 is a chemokine receptor that plays important roles in mediating chemotactic signals and modulating the activation of lymphocytes. We have previously conducted a case-control study by using a candidate gene approach to investigate the association of CXCR3 polymorphisms with the risk of asthma. Results from the epidemiologic study showed that a common nucleotide variant in the CXCR3 intron (rs2280964G>A) was associated with disease susceptibility (1006 cases and 384 control subjects; odds ratio, 0.81; 95% CI, 0.69-0.94; P = .007).
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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|
pubmed:month |
Dec
|
|
pubmed:issn |
1097-6825
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pubmed:author |
pubmed-author:ChangHun SooHS,
pubmed-author:ChoiJung-WonJW,
pubmed-author:HanBok-GheeBG,
pubmed-author:HwangMinyoungM,
pubmed-author:KimHyung LaeHL,
pubmed-author:KimYeonjungY,
pubmed-author:KimmKuchanK,
pubmed-author:NamHye-YoungHY,
pubmed-author:OhBermseokB,
pubmed-author:ParkChoon-SikCS,
pubmed-author:ParkSeong GyuSG
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|
pubmed:issnType |
Electronic
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pubmed:volume |
122
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pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
1119-1126.e7
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|
pubmed:meshHeading |
pubmed-meshheading:18962861-Adolescent,
pubmed-meshheading:18962861-Adult,
pubmed-meshheading:18962861-Aged,
pubmed-meshheading:18962861-Aged, 80 and over,
pubmed-meshheading:18962861-Alleles,
pubmed-meshheading:18962861-Asthma,
pubmed-meshheading:18962861-Case-Control Studies,
pubmed-meshheading:18962861-Cell Line, Transformed,
pubmed-meshheading:18962861-Chemokines,
pubmed-meshheading:18962861-Chemotaxis,
pubmed-meshheading:18962861-Child,
pubmed-meshheading:18962861-Child, Preschool,
pubmed-meshheading:18962861-Female,
pubmed-meshheading:18962861-Gene Expression Regulation,
pubmed-meshheading:18962861-Genetic Predisposition to Disease,
pubmed-meshheading:18962861-Humans,
pubmed-meshheading:18962861-Introns,
pubmed-meshheading:18962861-Lymphocyte Activation,
pubmed-meshheading:18962861-Male,
pubmed-meshheading:18962861-Middle Aged,
pubmed-meshheading:18962861-Polymorphism, Single Nucleotide,
pubmed-meshheading:18962861-Quantitative Trait Loci,
pubmed-meshheading:18962861-Receptors, CXCR3,
pubmed-meshheading:18962861-Signal Transduction,
pubmed-meshheading:18962861-T-Lymphocytes
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|
pubmed:year |
2008
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|
pubmed:articleTitle |
A common intronic variant of CXCR3 is functionally associated with gene expression levels and the polymorphic immune cell responses to stimuli.
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|
pubmed:affiliation |
Center for Genome Science, the National Institute of Health, Seoul, South Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Multicenter Study
|
