Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2008-11-25
pubmed:abstractText
Neuritic plaques in the brains are one of the pathological hallmarks of Alzheimer's disease (AD). Amyloid beta-protein (Abeta), the central component of neuritic plaques, is derived from beta-amyloid precursor protein (APP) after beta- and gamma-secretase cleavage. The molecular mechanism underlying the pathogenesis of AD is not yet well defined, and there has been no effective treatment for AD. Valproic acid (VPA) is one of the most widely used anticonvulsant and mood-stabilizing agents for treating epilepsy and bipolar disorder. We found that VPA decreased Abeta production by inhibiting GSK-3beta-mediated gamma-secretase cleavage of APP both in vitro and in vivo. VPA treatment significantly reduced neuritic plaque formation and improved memory deficits in transgenic AD model mice. We also found that early application of VPA was important for alleviating memory deficits of AD model mice. Our study suggests that VPA may be beneficial in the prevention and treatment of AD.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/18955571-10037507, http://linkedlifedata.com/resource/pubmed/commentcorrection/18955571-10206644, http://linkedlifedata.com/resource/pubmed/commentcorrection/18955571-10206645, http://linkedlifedata.com/resource/pubmed/commentcorrection/18955571-10359821, http://linkedlifedata.com/resource/pubmed/commentcorrection/18955571-10864326, http://linkedlifedata.com/resource/pubmed/commentcorrection/18955571-10878814, http://linkedlifedata.com/resource/pubmed/commentcorrection/18955571-11224535, http://linkedlifedata.com/resource/pubmed/commentcorrection/18955571-11224536, http://linkedlifedata.com/resource/pubmed/commentcorrection/18955571-11406613, http://linkedlifedata.com/resource/pubmed/commentcorrection/18955571-11418608, http://linkedlifedata.com/resource/pubmed/commentcorrection/18955571-11475940, http://linkedlifedata.com/resource/pubmed/commentcorrection/18955571-11679632, http://linkedlifedata.com/resource/pubmed/commentcorrection/18955571-11700559, http://linkedlifedata.com/resource/pubmed/commentcorrection/18955571-11907044, http://linkedlifedata.com/resource/pubmed/commentcorrection/18955571-12015604, http://linkedlifedata.com/resource/pubmed/commentcorrection/18955571-12093158, http://linkedlifedata.com/resource/pubmed/commentcorrection/18955571-12269862, http://linkedlifedata.com/resource/pubmed/commentcorrection/18955571-12376527, http://linkedlifedata.com/resource/pubmed/commentcorrection/18955571-12551931, http://linkedlifedata.com/resource/pubmed/commentcorrection/18955571-12660785, http://linkedlifedata.com/resource/pubmed/commentcorrection/18955571-12761548, http://linkedlifedata.com/resource/pubmed/commentcorrection/18955571-12794186, http://linkedlifedata.com/resource/pubmed/commentcorrection/18955571-12826675, http://linkedlifedata.com/resource/pubmed/commentcorrection/18955571-12943000, http://linkedlifedata.com/resource/pubmed/commentcorrection/18955571-13678586, http://linkedlifedata.com/resource/pubmed/commentcorrection/18955571-15170327, http://linkedlifedata.com/resource/pubmed/commentcorrection/18955571-15289451, http://linkedlifedata.com/resource/pubmed/commentcorrection/18955571-15585578, http://linkedlifedata.com/resource/pubmed/commentcorrection/18955571-15687223, http://linkedlifedata.com/resource/pubmed/commentcorrection/18955571-15857888, http://linkedlifedata.com/resource/pubmed/commentcorrection/18955571-15890777, http://linkedlifedata.com/resource/pubmed/commentcorrection/18955571-16230462, http://linkedlifedata.com/resource/pubmed/commentcorrection/18955571-16375658, http://linkedlifedata.com/resource/pubmed/commentcorrection/18955571-16449801, http://linkedlifedata.com/resource/pubmed/commentcorrection/18955571-16641999, http://linkedlifedata.com/resource/pubmed/commentcorrection/18955571-16816112, http://linkedlifedata.com/resource/pubmed/commentcorrection/18955571-17121991, http://linkedlifedata.com/resource/pubmed/commentcorrection/18955571-17148938, http://linkedlifedata.com/resource/pubmed/commentcorrection/18955571-17468743, http://linkedlifedata.com/resource/pubmed/commentcorrection/18955571-6375662, http://linkedlifedata.com/resource/pubmed/commentcorrection/18955571-7596406, http://linkedlifedata.com/resource/pubmed/commentcorrection/18955571-7638622, http://linkedlifedata.com/resource/pubmed/commentcorrection/18955571-7651536, http://linkedlifedata.com/resource/pubmed/commentcorrection/18955571-9065401, http://linkedlifedata.com/resource/pubmed/commentcorrection/18955571-9450754
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1540-9538
pubmed:author
pubmed:issnType
Electronic
pubmed:day
24
pubmed:volume
205
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2781-9
pubmed:dateRevised
2011-11-2
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