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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2008-11-10
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pubmed:abstractText |
A dynamic equilibrium between proliferation and programmed cell death (PCD) of auto-reactive T lymphocytes plays a pivotal role in the prevention of autoimmune diseases. We analyzed T lymphocytes myelin basic protein (MBP)-specific PCD and proliferation in demyelinating diseases. Results showed that MBP-specific PCD was significantly decreased in CD4+ and CD8+ T lymphocytes of progressive multifocal leukoencephalopathy (PML), not determined leukoencephalopathy (NDLE), and acute MS (AMS) patients compared to patients with stable MS (SMS) and healthy controls. MBP-specific proliferation/PCD rates were high in CD4+ T lymphocytes of PML, NDLE, and AMS patients, and in CD8+ T cells of PML and AMS individuals alone. Alterations of the balance between MBP-specific proliferation and PCD are present in demyelinating diseases and could play a major role in the pathogenesis of these diseases.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18930441-10025799,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18930441-10718540,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18930441-10986412,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18930441-11101867,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18930441-11750036,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18930441-11953468,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18930441-12410486,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18930441-12709872,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18930441-14581528,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18930441-14976054,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18930441-15167073,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18930441-15623736,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18930441-15780734,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18930441-15804959,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18930441-16161213,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18930441-16750575,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18930441-16862584,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18930441-17613717,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18930441-18045134,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18930441-18161756,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18930441-9461328,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18930441-9677163,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18930441-9764796,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18930441-9776571
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1521-7035
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
129
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
509-17
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pubmed:dateRevised |
2011-10-6
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pubmed:meshHeading |
pubmed-meshheading:18930441-Adult,
pubmed-meshheading:18930441-Amino Acid Sequence,
pubmed-meshheading:18930441-Apoptosis,
pubmed-meshheading:18930441-CD4-Positive T-Lymphocytes,
pubmed-meshheading:18930441-CD8-Positive T-Lymphocytes,
pubmed-meshheading:18930441-Cell Proliferation,
pubmed-meshheading:18930441-Cytokines,
pubmed-meshheading:18930441-DNA, Viral,
pubmed-meshheading:18930441-Demyelinating Diseases,
pubmed-meshheading:18930441-Female,
pubmed-meshheading:18930441-Flow Cytometry,
pubmed-meshheading:18930441-Humans,
pubmed-meshheading:18930441-JC Virus,
pubmed-meshheading:18930441-Leukocytes, Mononuclear,
pubmed-meshheading:18930441-Lymphocyte Activation,
pubmed-meshheading:18930441-Male,
pubmed-meshheading:18930441-Middle Aged,
pubmed-meshheading:18930441-Molecular Sequence Data,
pubmed-meshheading:18930441-Myelin Basic Proteins,
pubmed-meshheading:18930441-Peptide Fragments,
pubmed-meshheading:18930441-Polymerase Chain Reaction,
pubmed-meshheading:18930441-Young Adult
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pubmed:year |
2008
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pubmed:articleTitle |
Myelin basic protein-specific T lymphocytes proliferation and programmed cell death in demyelinating diseases.
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pubmed:affiliation |
Laboratory of Molecular Medicine and Biotechnology, Don C. Gnocchi Foundation ONLUS, IRCCS S. Maria Nascente, Via Capecelatro 66, 20148, Milan, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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