18929484

Source:http://linkedlifedata.com/resource/pubmed/id/18929484

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0205314, umls-concept:C0243077, umls-concept:C0679622, umls-concept:C1579259
pubmed:issue	23
pubmed:dateCreated	2008-11-13
pubmed:abstractText	The synthesis and biological activities of imidazo[5,1-f][1,2,4]triazin-2-amines (imidazotriazines) as novel polo-like kinase 1 inhibitors are reported.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9107377
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Amines, http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents, http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Imidazoles, http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases, http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Triazines, http://linkedlifedata.com/resource/pubmed/chemical/polo-like kinase 1
pubmed:status	MEDLINE
pubmed:month	Dec
pubmed:issn	1464-3405
pubmed:author	pubmed-author:AndrewsC WCW3rd, pubmed-author:CheungMM, pubmed-author:EpperlyA HAH, pubmed-author:HasslerD FDF, pubmed-author:KuntzK WKW, pubmed-author:LansingT JTJ, pubmed-author:LeesnitzerM AMA, pubmed-author:MookR ARAJr, pubmed-author:PobanzMM, pubmed-author:SalovichJ MJM, pubmed-author:ShewchukL MLM, pubmed-author:SmithG KGK, pubmed-author:SmithJ LJL, pubmed-author:WilsonB JBJ
pubmed:issnType	Electronic
pubmed:day	1
pubmed:volume	18
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	6214-7
pubmed:dateRevised	2011-11-2
pubmed:meshHeading	pubmed-meshheading:18929484-Administration, Oral, pubmed-meshheading:18929484-Amines, pubmed-meshheading:18929484-Animals, pubmed-meshheading:18929484-Antineoplastic Agents, pubmed-meshheading:18929484-Cell Cycle Proteins, pubmed-meshheading:18929484-Combinatorial Chemistry Techniques, pubmed-meshheading:18929484-Crystallography, X-Ray, pubmed-meshheading:18929484-Drug Screening Assays, Antitumor, pubmed-meshheading:18929484-Imidazoles, pubmed-meshheading:18929484-Mice, pubmed-meshheading:18929484-Models, Molecular, pubmed-meshheading:18929484-Molecular Conformation, pubmed-meshheading:18929484-Molecular Structure, pubmed-meshheading:18929484-Protein-Serine-Threonine Kinases, pubmed-meshheading:18929484-Proto-Oncogene Proteins, pubmed-meshheading:18929484-Structure-Activity Relationship, pubmed-meshheading:18929484-Triazines
pubmed:year	2008
pubmed:articleTitle	Imidazo[5,1-f][1,2,4]triazin-2-amines as novel inhibitors of polo-like kinase 1.
pubmed:affiliation	GlaxoSmithKline, Fire Moore Drive, Research Triangle Park, NC 27709, USA. mui.h.cheung@gsk.com
pubmed:publicationType	Journal Article