Linked Life Data

18927449

Source:http://linkedlifedata.com/resource/pubmed/id/18927449

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2008-12-30
pubmed:abstractText
Notch signaling activity regulates arteriogenesis. Presenilin 1 (PS1) mediates Notch signaling activity via cleavage of Notch, liberating Notch intracellular domain (NICD). We tested the hypothesis that simvastatin enhances arteriogenesis after stroke by increasing PS1 activation of the Notch signaling pathway.
pubmed:grant
pubmed:commentsCorrections
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pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1524-4628
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
40
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
254-60
pubmed:dateRevised
2010-12-17
pubmed:meshHeading
pubmed-meshheading:18927449-Animals, pubmed-meshheading:18927449-Brain, pubmed-meshheading:18927449-Cell Movement, pubmed-meshheading:18927449-Cerebral Arteries, pubmed-meshheading:18927449-Cerebrovascular Circulation, pubmed-meshheading:18927449-Disease Models, Animal, pubmed-meshheading:18927449-Hydroxymethylglutaryl-CoA Reductase Inhibitors, pubmed-meshheading:18927449-Male, pubmed-meshheading:18927449-Microcirculation, pubmed-meshheading:18927449-Myocytes, Smooth Muscle, pubmed-meshheading:18927449-Neovascularization, Physiologic, pubmed-meshheading:18927449-Organ Culture Techniques, pubmed-meshheading:18927449-Presenilin-1, pubmed-meshheading:18927449-Rats, pubmed-meshheading:18927449-Rats, Wistar, pubmed-meshheading:18927449-Receptor, Notch1, pubmed-meshheading:18927449-Recovery of Function, pubmed-meshheading:18927449-Signal Transduction, pubmed-meshheading:18927449-Simvastatin, pubmed-meshheading:18927449-Stroke, pubmed-meshheading:18927449-Treatment Outcome, pubmed-meshheading:18927449-Up-Regulation
pubmed:year
2009
pubmed:articleTitle
Simvastatin increases notch signaling activity and promotes arteriogenesis after stroke.
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