Linked Life Data

18924443

Source:http://linkedlifedata.com/resource/pubmed/id/18924443

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2008-10-17
pubmed:abstractText
Gastric motility is controlled at various levels including the enteric nervous system (ENS). The gastric ENS is involved in the regulation of accommodation reflexes as well as of the peristaltic waves which are responsible for grinding and emptying. Polarised projections consisting of ascending cholinergic and descending nitrergic muscle motor neurons make up the hard wired circuits for control of muscle activity. In an isolated flat sheet preparation of the gastric corpus we investigated stretch evoked responses. The responses at the site of the distension as well as proximal and distal to the distension consisted of a cholinergic excitation whereas a nitrergic inhibition was only observed at the site of the distension stimulus. At all sites the responses were significantly reduced by the neurotoxin tetrodotoxin suggesting a neural component. In addition the nicotinic blocker hexamethonium reduced the responses at all sites to the same degree as tetrodotoxin which indicated the strong contribution of ascending and descending cholinergic interneurons. The reflexes of isolated gastric corpus preparations to distension are dominated by excitatory responses. Only the muscle response at the site of distension exhibited an inhibitory response which is usually dominated by the cholinergic excitatory response.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1128-3602
pubmed:author
pubmed:issnType
Print
pubmed:volume
12 Suppl 1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
41-51
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Motor control of the stomach.
pubmed:affiliation
Human Biology, Technische Universität München, Freising, Germany. schemann@wzw.tum.de
pubmed:publicationType
Journal Article, Review