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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2009-3-26
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pubmed:abstractText |
LL-37 is a human cathelicidin antimicrobial peptide that is released in the skin after injury and acts to defend against infection and modulate the local cellular immune response. We observed in human dermal keloids that fibrosis was inversely related to the expression of cathelicidin and sought to determine how LL-37 influenced expression of types I and III collagen genes in dermal fibroblasts. At nano-molar concentrations, LL-37 inhibited baseline and transforming growth factor-beta-induced collagen expression. At these concentrations, LL-37 also induced phosphorylation of extracellular signal-regulated kinase (ERK) within 30 minutes. Activation of ERK, and the activation of a G-protein-dependent pathway, was essential for inhibition of collagen expression as pertussis toxin or an inhibitor of ERK blocked the inhibitory effects of LL-37. c-Jun N-terminal kinase and p38 mitogen-activated protein kinase inhibitors did not alter the effects of cathelicidin. Silencing of the Ets-1 reversed inhibitory effects of LL-37. Taken together, these findings show that LL-37 can directly act on dermal fibroblasts and may have antifibrotic action during the wound repair process.
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pubmed:grant |
http://linkedlifedata.com/resource/pubmed/grant/AI052453,
http://linkedlifedata.com/resource/pubmed/grant/AR45676,
http://linkedlifedata.com/resource/pubmed/grant/R01 AI052453-01,
http://linkedlifedata.com/resource/pubmed/grant/R01 AI052453-02,
http://linkedlifedata.com/resource/pubmed/grant/R01 AI052453-03,
http://linkedlifedata.com/resource/pubmed/grant/R01 AI052453-04,
http://linkedlifedata.com/resource/pubmed/grant/R01 AI052453-05,
http://linkedlifedata.com/resource/pubmed/grant/R01 AI052453-06,
http://linkedlifedata.com/resource/pubmed/grant/R01 AI052453-07,
http://linkedlifedata.com/resource/pubmed/grant/R01 AR052728-01A1,
http://linkedlifedata.com/resource/pubmed/grant/R01 AR052728-02,
http://linkedlifedata.com/resource/pubmed/grant/R01 AR052728-03,
http://linkedlifedata.com/resource/pubmed/grant/R01 AR052728-04
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18923445-10385284,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18923445-11442754,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18923445-11719807,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18923445-11919190,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18923445-12111349,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18923445-12374875,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18923445-12594247,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18923445-12782665,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18923445-12782669,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18923445-14645373,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18923445-15208269,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18923445-15507107,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18923445-16738537,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18923445-16936092,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18923445-17164998,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18923445-17332879,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18923445-17332880,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18923445-17332883,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18923445-17367817,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18923445-7589491,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18923445-7972004
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1523-1747
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
129
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
843-50
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pubmed:dateRevised |
2010-9-20
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pubmed:meshHeading |
pubmed-meshheading:18923445-Antimicrobial Cationic Peptides,
pubmed-meshheading:18923445-Cells, Cultured,
pubmed-meshheading:18923445-Collagen,
pubmed-meshheading:18923445-Fibroblasts,
pubmed-meshheading:18923445-Humans,
pubmed-meshheading:18923445-Keloid,
pubmed-meshheading:18923445-MAP Kinase Signaling System,
pubmed-meshheading:18923445-Pertussis Toxin,
pubmed-meshheading:18923445-Proto-Oncogene Protein c-ets-1,
pubmed-meshheading:18923445-Skin,
pubmed-meshheading:18923445-Transforming Growth Factor beta
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pubmed:year |
2009
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pubmed:articleTitle |
Collagen synthesis is suppressed in dermal fibroblasts by the human antimicrobial peptide LL-37.
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pubmed:affiliation |
Department of Dermatology, St Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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