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rdf:type |
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|
lifeskim:mentions |
|
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pubmed:issue |
4
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pubmed:dateCreated |
1991-10-10
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pubmed:abstractText |
In this study, the relationship between the dCTP/ara-CTP ratio and the cytotoxic effect of cytosine arabinoside (ara-C) was investigated. Intracellular levels of dNTPs and ara-CTP were analyzed by high-performance liquid chromatography. Although doubling time and intracellular dCTP levels were different in each of the cells, there was a consistent relation between the intracellular dCTP/ara-CTP ratio and the cytotoxic concentration of ara-C. These data suggest that the intracellular dCTP/ara-CTP ratio is one of the important factors for considering the cytotoxic action of ara-C.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
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|
pubmed:status |
MEDLINE
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pubmed:issn |
0735-7907
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
9
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
409-13
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:1884247-Arabinofuranosylcytosine Triphosphate,
pubmed-meshheading:1884247-Cell Division,
pubmed-meshheading:1884247-Chromatography, High Pressure Liquid,
pubmed-meshheading:1884247-Culture Media,
pubmed-meshheading:1884247-Cytarabine,
pubmed-meshheading:1884247-DNA, Neoplasm,
pubmed-meshheading:1884247-Deoxycytosine Nucleotides,
pubmed-meshheading:1884247-Humans,
pubmed-meshheading:1884247-Tumor Cells, Cultured
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|
pubmed:year |
1991
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|
pubmed:articleTitle |
Intracellular dCTP/ara-CTP ratio and the cytotoxic effect of ara-C.
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pubmed:affiliation |
Department of Pediatrics, Mie University School of Medicine, Japan.
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pubmed:publicationType |
Journal Article
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