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rdf:type |
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lifeskim:mentions |
umls-concept:C0086418,
umls-concept:C0087111,
umls-concept:C0144576,
umls-concept:C0334227,
umls-concept:C0664336,
umls-concept:C0812230,
umls-concept:C1140680,
umls-concept:C1511545,
umls-concept:C1521840,
umls-concept:C1704259,
umls-concept:C1705987
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pubmed:issue |
2
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pubmed:dateCreated |
2008-12-16
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pubmed:abstractText |
Although multiple mechanisms have been implicated in paclitaxel (PTX)-induced resistance in ovarian cancer, recent evidence has suggested that Akt2 has an important role in the protection of cells from paclitaxel-induced apoptosis. In the present study, we investigated the role of the Akt2/survivin pathway in paclitaxel-induced resistance by a modified method to generate an effective shRNA vector.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/AKT2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/BIRC5 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Inhibitor of Apoptosis Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Microtubule-Associated Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Paclitaxel,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-akt,
http://linkedlifedata.com/resource/pubmed/chemical/Tetrazolium Salts,
http://linkedlifedata.com/resource/pubmed/chemical/Thiazoles,
http://linkedlifedata.com/resource/pubmed/chemical/thiazolyl blue
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1872-7980
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pubmed:author |
pubmed-author:DeanA CAC,
pubmed-author:KIMS WSW,
pubmed-author:LiZ BZB,
pubmed-author:MaXiaoliX,
pubmed-author:MengLiL,
pubmed-author:SongXiaohongX,
pubmed-author:WangShixuanS,
pubmed-author:WengDanhuiD,
pubmed-author:WengYanjieY,
pubmed-author:XingHuiH,
pubmed-author:XuGangG,
pubmed-author:ZhouJianfengJ
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pubmed:issnType |
Electronic
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pubmed:day |
18
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pubmed:volume |
273
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
257-65
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:18842333-Apoptosis,
pubmed-meshheading:18842333-Base Sequence,
pubmed-meshheading:18842333-Cell Line, Tumor,
pubmed-meshheading:18842333-Cell Proliferation,
pubmed-meshheading:18842333-Cell Separation,
pubmed-meshheading:18842333-Female,
pubmed-meshheading:18842333-Flow Cytometry,
pubmed-meshheading:18842333-Humans,
pubmed-meshheading:18842333-Inhibitor of Apoptosis Proteins,
pubmed-meshheading:18842333-Microtubule-Associated Proteins,
pubmed-meshheading:18842333-Molecular Sequence Data,
pubmed-meshheading:18842333-Neoplasm Proteins,
pubmed-meshheading:18842333-Ovarian Neoplasms,
pubmed-meshheading:18842333-Paclitaxel,
pubmed-meshheading:18842333-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:18842333-RNA Interference,
pubmed-meshheading:18842333-Tetrazolium Salts,
pubmed-meshheading:18842333-Thiazoles
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pubmed:year |
2009
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pubmed:articleTitle |
Implication of the Akt2/survivin pathway as a critical target in paclitaxel treatment in human ovarian cancer cells.
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pubmed:affiliation |
Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, PR China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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