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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
44
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pubmed:dateCreated |
2008-10-29
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pubmed:abstractText |
We report a new strategy for coupling chromone to Fe3O4 nanoparticles. The chromone-Fe3O4 NP conjugate shows a dramatic increase in chromone solubility in cell culture medium from less than 2.5 to 633 microg/ml, leading to the enhanced chromone uptake by HeLa cells. Chromone can be released at low pH and as a result, the chromone-Fe3O4 conjugate is much more efficient in inhibiting the HeLa cell proliferation. Such chromone-Fe3O4 NPs are promising as a powerful multifunctional delivery system for both chromone-based diagnostic and therapeutic applications.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18839952-10706520,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18839952-10848895,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18839952-11562277,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18839952-15898772,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18839952-15934780,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18839952-16150582,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18839952-16443308,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18839952-16789737,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18839952-17193123,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18839952-17934800,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18839952-18080259
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1520-5126
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
5
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pubmed:volume |
130
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
14436-7
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:18839952-Aldehydes,
pubmed-meshheading:18839952-Biocompatible Materials,
pubmed-meshheading:18839952-Chromones,
pubmed-meshheading:18839952-Culture Media,
pubmed-meshheading:18839952-Dopamine,
pubmed-meshheading:18839952-Drug Delivery Systems,
pubmed-meshheading:18839952-Ferumoxytol,
pubmed-meshheading:18839952-HeLa Cells,
pubmed-meshheading:18839952-Humans,
pubmed-meshheading:18839952-Hydrogen-Ion Concentration,
pubmed-meshheading:18839952-Nanoparticles,
pubmed-meshheading:18839952-Polyethylene Glycols,
pubmed-meshheading:18839952-Solubility
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pubmed:year |
2008
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pubmed:articleTitle |
pH controlled release of chromone from chromone-Fe3O4 nanoparticles.
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pubmed:affiliation |
Department of Chemistry, Brown University, Providence, Rhode Island 02912, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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